Results 111 to 120 of about 1,854,304 (344)

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

AI-Enhanced Metaheuristics Control for Project Scheduling Using Neural Networks

IEEE Access
Project management requires systematically planning and allocating time, resources, and people to complete complex projects. A well-known problem in project management is the Resource-Constrained Project Scheduling Problem (RCPSP), which seeks to ...
Nikolaos T. Mitsou, Georgios K. Koulinas
doaj   +1 more source

Managing uncertainty in innovation project portfolios : tasks of managers and steering committees

, 2021
Innovation project portfolios as organizations’ strategic investments face uncertainties both within the organization and in the business context. Management of such uncertainties is distributed in the organizations and requires cooperation, but it may be challenging to coordinate in and across the complex portfolios.
Martinsuo, Miia, Tuominen, Siiri
openaire   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Flat-plate solar array project. Volume 8: Project analysis and integration [PDF]

Project Analysis and Integration (PA&I) performed planning and integration activities to support management of the various Flat-Plate Solar Array (FSA) Project R&D activities. Technical and economic goals were established by PA&I for each R&D task within
Henry, P., Mcguire, P.
core   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

DEVELOPMENT OF INFORMATION TECHNOLOGY FOR INTELLIGENT PLANNING OF THE IT PROJECT TEAM'S WORK BASED ON A FLEXIBLE METHODOLOGY

Вісник Національного технічного університету «ХПÌ». Серія: Стратегічне управління, управління портфелями, програмами та проектами
The subject of the study is the development of information technology for intelligent planning of the IT project team. The purpose of the study is to reduce project risks associated with the perception of tasks and their distribution among team members ...
Марина Гринченко, Микита Роговий, Євген Грінченко   +2 more
doaj   +1 more source

Care for a Patient With Cancer As a Project: Management of Complex Task Interdependence in Cancer Care Delivery [PDF]

, 2016
Julia R. Trosman, Ruth C. Carlos, Melissa A. Simon, Debra Madden, William J. Gradishar, Al B. Benson, Bruce D. Rapkin, Elisa S. Weiss, Ilana F. Gareen, Lynne I. Wagner, Seema A. Khan, Mikele Bunce, Art Small, Christine B. Weldon   +13 more
openalex   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source