Results 91 to 100 of about 1,854,304 (344)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Generalization of the critical chain method supporting the management of projects with a high degree of uncertainty and imperfect information [PDF]
In the critical chain method the fundamental notion is the project buffer, and its length is based on task estimation risk. This estimation is almost never unequivocal. If it is not correct, the whole method may turn out to be ineffective.
Dorota Kuchta
core
, 2019 In this new book we return to the challenge of deepening the task to the point of imagining the university formed by commoner university students. It is a turn, a new place from which to name and reconsider community management and action from a sense of
Altamirano Chingay, Karla +10 more
core
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
CONTEMPORARY PROBLEMS AND TASKS IN MANAGEMENT OF PROJECT PORTFOLIO
Bulletin of NTU "KhPI". Series: Strategic Management, Portfolio, Program and Project Management, 2015 The article highlights the main challenges and contemporary issues in portfolio management, since project portfolio management process is significantly different from the one project managing, its in fact, is a procedure of a higher level and has different goals and means of their achievement.
openaire +3 more sources
Classes of decision analysis [PDF]
, 2016 The ultimate task of an engineer consists of developing a consistent decision procedure for the planning, design, construction and use and management of a project.
Caspeele, Robby +2 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Estimation of the resource buffers in the assembly process of a shearer machine in the CPPM method
MATEC Web of Conferences, 2017 Dynamic development of scheduling systems allows significantly improving currently realized tasks. Critical Chain Project Management (CCPM) is one of the methods of project management basing on network planning.
Gwiazda Aleksander +2 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source