Results 1 to 10 of about 22,611 (98)

Effects of the tat and nef gene products of human immunodeficiency virus type 1 (HIV-1) on transcription controlled by the HIV-1 long terminal repeat and on cell growth in macrophages [PDF]

Journal of Virology, 1993
The RAW264 murine macrophage cell line was used as a model to examine the role of the tat and nef gene products in the transcription regulation of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) in macrophages. Contrary to claims that the activity of the HIV-1 LTR responds poorly in rodent cells to trans activation by the ...
Murphy, Kathleen M., Sweet, Matthew J., Ross, Ian L., Hume, David A.   +3 more
openaire   +7 more sources

Analysis of multiply spliced transcripts in lymphoid tissue reservoirs of rhesus macaques infected with RT-SHIV during HAART. [PDF]

, 2014
Highly active antiretroviral therapy (HAART) can reduce levels of human immunodeficiency virus type 1 (HIV-1) to undetectable levels in infected individuals, but the virus is not eradicated.
Adamson, Lourdes, Cannavo, Elda, Deere, Jesse D, Higgins, Joanne, Kauffman, Robert C, Luciw, Paul A, North, Thomas W, Schinazi, Raymond F, Villalobos, Andradi   +8 more
core   +11 more sources

Potent Inhibition of Human Immunodeficiency Virus Type 1 (HIV-1) Gene Expression and Virus Production by an HIV-2 Tat Activation-Response RNA Decoy [PDF]

Journal of Virology, 1999
ABSTRACT Tat activation-response region (TAR) decoys have been developed for use in gene therapy for people infected with human immunodeficiency virus type 1 (HIV-1). When a TAR RNA decoy is overexpressed, it will bind Tat, thus leaving less of this crucial protein to bind to and activate the natural transcriptional promoter of HIV-1 ...
C M, Browning, L, Cagnon, P D, Good, J, Rossi, D R, Engelke, D M, Markovitz   +5 more
openaire   +2 more sources

Hyper-responsiveness to Stimulation of Human Immunodeficiency Virus-infected CD4+ T Cells Requires Nef and Tat Virus Gene Products and Results from Higher NFAT, NF-κB, and AP-1 Induction [PDF]

Journal of Biological Chemistry, 2004
A chronic state of immune hyperactivation is a feature of human immunodeficiency virus type-1 (HIV-1) infection. Studies on the molecular mechanisms by which HIV-1 can modulate the activation state of T cells indicate that both Nef and Tat can alter T cell activation.
Jean-François, Fortin, Corinne, Barat, Yannick, Beauséjour, Benoit, Barbeau, Michel J, Tremblay   +4 more
openaire   +2 more sources

Dynamic Post-Transcriptional Regulation of HIV-1 Gene Expression

Biology, 2012
Gene expression of the human immunodeficiency virus type 1 (HIV-1) is a highly regulated process. Basal transcription of the integrated provirus generates early transcripts that encode for the viral products Tat and Rev.
Alessandro Marcello, Anna Kula
doaj   +1 more source

Human herpesvirus-8 (Kaposi’s sarcoma-associated herpesvirus) ORF50 interacts synergistically with the tat gene product in transactivating the human immunodeficiency virus type 1 LTR

Journal of General Virology, 2001
Human herpesvirus-8 (HHV-8) is a lymphotropic virus associated with several AIDS-related neoplasms. Two ORFs play a critical role in the regulation of virus replication: ORF50, encoding an immediate-early transcriptional activator, and ORF57, encoding a post-transcriptional regulator.
CASELLI, Elisabetta, MENEGAZZI P, BRACCI A, GALVAN M, CASSAI, Enzo, DI LUCA, Dario   +5 more
openaire   +2 more sources

Targeted Derepression of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat by Pyrrole-Imidazole Polyamides [PDF]

, 2002
The host factor LSF represses the human immunodeficiency virus type 1 long terminal repeat (LTR) by mediating recruitment of histone deacetylase. We show that pyrrole-imidazole polyamides targeted to the LTR can specifically block LSF binding both in ...
Coull, Jason J., Dervan, Peter B., He, Guocheng, Margolis, David M., Melander, Christian, Rucker, Victor C.   +5 more
core   +1 more source

Nuclear factor-kappa B family member RelB inhibits human immunodeficiency virus-1 Tat-induced tumor necrosis factor-alpha production.

PLoS ONE, 2010
Human Immunodeficiency Virus-1 (HIV-1)-associated neurocognitive disorder (HAND) is likely neuroinflammatory in origin, believed to be triggered by inflammatory and oxidative stress responses to cytokines and HIV protein gene products such as the HIV ...
Michelle Kiebala, Oksana Polesskaya, Zhenqiang Yao, Seth W Perry, Sanjay B Maggirwar   +4 more
doaj   +1 more source

Activation of Egr-1 expression in astrocytes by HIV-1 Tat: new insights into astrocyte-mediated Tat neurotoxicity [PDF]

, 2011
Human immunodeficiency virus type 1 (HIV-1) Tat plays an important role in HIV-associated neuropathogenesis; the underlying mechanisms are still evolving. We have recently shown that HIV-1 Tat induces expression of glial fibrillary acidic protein (GFAP),
Fan, Yan, Green, Linden A., He, Johnny J., oh Kim, Byung, Zou, Wei   +4 more
core   +1 more source

Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage

Retrovirology, 2009
Human immunodeficiency virus type 1 (HIV-1) has been shown to replicate productively in cells of the monocyte-macrophage lineage, although replication occurs to a lesser extent than in infected T cells.
Shah Sonia, Kilareski Evelyn M, Nonnemacher Michael R, Wigdahl Brian   +3 more
doaj   +1 more source