Results 251 to 260 of about 5,125 (296)
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Tat-neutralizing versus Tat-protecting antibodies in rhesus macaques vaccinated with Tat peptides

Vaccine, 2005
The human immunodeficiency virus (HIV) regulatory protein Tat represents an attractive target for developing vaccine strategies. Both humoral and cellular responses against Tat might reduce disease progression by interfering with the deleterious functions of extracellularly secreted protein and by reducing viral replication.
Guillaume, Belliard   +9 more
openaire   +2 more sources

Decoding Tat: the biology of HIV Tat posttranslational modifications

Microbes and Infection, 2005
The Tat protein is a viral transactivator that activates HIV transcription through complex interactions with RNA and host cell factors. Tat undergoes multiple posttranslational modifications that regulate the dynamics and complexity of these interactions. The biology of these modifications and their role in Tat function are reviewed.
Claudia, Hetzer   +3 more
openaire   +2 more sources

HIV tat and neurotoxicity

Microbes and Infection, 2006
HIV tat is the transactivator of HIV-1, supporting efficient viral replication by stabilizing the transcription of viral genes. Tat can be released from HIV-infected cells and alter several functions in uninfected cells. In the brain, tat induces neuronal dysfunction/toxicity, even though neurons cannot be directly infected with HIV, resulting in CNS ...
J E, King   +3 more
openaire   +2 more sources

The Stimulus Value of the TAT

Journal of Projective Techniques and Personality Assessment, 1965
Abstract Ratings of all 30 TAT cards were obtained from 34 male and 40 female college students on the following 10 bipolar, adjectival scales: accepting-rejecting, aggressive-passive, dependent-independent, happy-sad, hopeful-hopeless, impulsive-controlled, pleasant-unpleasant, safe-dangerous, severe-lenient, and sexy-sexless.
M R, GOLDFRIED, M, ZAX
openaire   +2 more sources

A minimal lentivirus Tat

Journal of Virology, 1991
Transcriptional regulatory mechanisms found in lentiviruses employ RNA enhancer elements called trans-activation responsive (TAR) elements. These nascent RNA stem-loops are cis-acting targets of virally encoded Tat effectors. Interactions between Tat and TAR increase the processivity of transcription complexes and lead to efficient copying of viral ...
D, Derse   +3 more
openaire   +2 more sources

Pharmacokinetics and Delivery of Tat and Tat-Protein Conjugates to Tissues in Vivo

Bioconjugate Chemistry, 2001
The membrane permeation in vivo of therapeutic proteins may be enhanced by conjugation of the protein to cationic import peptides, such as the tat protein of the human immune deficiency virus. The organ uptake, expressed as a percent of injected dose (ID) per gram of tissue, is a function of both membrane permeability and the area under the plasma ...
H J, Lee, W M, Pardridge
openaire   +2 more sources

TAT-1 and Deregulation

IEEE GLOBECOM 2008 - 2008 IEEE Global Telecommunications Conference, 2008
TAT-1, the first transatlantic telephone system, came into service in 1956. Its design was dominated by the need for reliability. Coincidentally, the process of the deregulation of the telephone industry began the very same year. This process has led to the current competitive environment.
openaire   +1 more source

Treatment of Time in the TAT

Journal of Projective Techniques and Personality Assessment, 1969
Summary Part of a larger empirical investigation to identify and classify subjective probability notions and explore their relationship to personality variables (Lipgar, 1965). Four factors that distinguished four types of subjective probability notions had been obtained from a matrix of intercorrelations among 30 Ss' Q sort ratings on patterns of ...
openaire   +2 more sources

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