Results 41 to 50 of about 5,125 (296)
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Highly expressed proteins have an increased frequency of alanine in the second amino acid position
BMC Genomics, 2006 Background Although the sequence requirements for translation initiation regions have been frequently analysed, usually the highly expressed genes are not treated as a separate dataset. Results To investigate this, we analysed the mRNA regions downstream
Remm Maido, Tats Age, Tenson Tanel
doaj +1 more source
eLife, 2016 A virus protein called Tat plays a dual role in HIV infection by regulating the expression of genes belonging to the virus and genes belonging to the host cells.
Barboric, Matjaz, Fujinaga, Koh
openaire +4 more sources
Automatisation du processus de mise en place des ?tats financiers : application : KPMG Alg?rie [PDF]
, 2022 M?moire de Projet de Fin d??tudes : G?nie Industriel. Management industriel : Alger, ?cole Nationale Polytechnique : 2022.L?objectif de ce travail est d?automatiser moyennant le Robotic Process Automation (RPA) le processus m?tier de mise en place des ...
Benmeradi, Hynd Manel, Ould Taleb, Anya
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Preferred and avoided codon pairs in three domains of life
BMC Genomics, 2008 Background Alternative synonymous codons are not used with equal frequencies. In addition, the contexts of codons – neighboring nucleotides and neighboring codons – can have certain patterns.
Tenson Tanel, Tats Age, Remm Maido
doaj +1 more source
Combination with anti-tit-for-tat remedies problems of tit-for-tat [PDF]
Journal of Theoretical Biology, 2017 One of the most important questions in game theory concerns how mutual cooperation can be achieved and maintained in a social dilemma. In Axelrod's tournaments of the iterated prisoner's dilemma, Tit-for-Tat (TFT) demonstrated the role of reciprocity in the emergence of cooperation.
Yi, Su Do +2 more
openaire +4 more sources
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Comparative Analysis of Tat-Dependent and Tat-Deficient Natural Lentiviruses [PDF]
Veterinary Sciences, 2015 The emergence of human immunodeficiency virus (HIV) causing acquired immunodeficiency syndrome (AIDS) in infected humans has resulted in a global pandemic that has killed millions. HIV-1 and HIV-2 belong to the lentivirus genus of the Retroviridae family.
Bose, Deepanwita +2 more
openaire +4 more sources
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source