Results 41 to 50 of about 360,326 (249)
Nature Network Boston, 2020 Development of tau-based therapies for Alzheimer’s disease requires an understanding of the timing of disease-related changes in tau. We quantified the phosphorylation state at multiple sites of the tau protein in cerebrospinal fluid markers across four ...
Nicolas R. Barthélemy +116 more
semanticscholar +1 more source
A survey of telerobotic surface finishing
Open Engineering, 2018 This is a survey of research published on the subjects of telerobotics, haptic feedback, and mixed reality applied to surface finishing. The survey especially focuses on how visuo-haptic feedback can be used to improve a grinding process using a remote ...
Höglund Thomas +2 more
doaj +1 more source
Neoplasia: An International Journal for Oncology Research, 2005 Atypical retinoids are potent inducers of apoptosis, but activation of the apoptotic pathway seems to be independent of retinoid receptors. Previous studies with a novel adamantyl retinoid, ST1926, have shown that apoptosis induction is associated with ...
Valentina Zuco +11 more
doaj +1 more source
LRP1 is a master regulator of tau uptake and spread
Nature, 2020 The spread of protein aggregates during disease progression is a common theme underlying many neurodegenerative diseases. The microtubule-associated protein tau has a central role in the pathogenesis of several forms of dementia known as tauopathies ...
J. N. Rauch +12 more
semanticscholar +1 more source
Cryo-EM structures of Tau filaments from Alzheimer’s disease brain
Nature, 2017 Alzheimer’s disease is the most common neurodegenerative disease, and there are no mechanism-based therapies. The disease is defined by the presence of abundant neurofibrillary lesions and neuritic plaques in the cerebral cortex.
A. Fitzpatrick +9 more
semanticscholar +1 more source
Novel tau filament fold in corticobasal degeneration
Nature, 2020 Corticobasal degeneration (CBD) is a neurodegenerative tauopathy—a class of disorders in which the tau protein forms insoluble inclusions in the brain—that is characterized by motor and cognitive disturbances 1 – 3 .
Wenjuan Zhang +14 more
semanticscholar +1 more source
Cogent Psychology, 2022 This study aimed to investigate the relationship between security, individuality, reputation on cognitive trust, perceived risk, consumer attitudes, and purchase intention of online shopping.
Van Dat Tran, Tuan Dat Nguyen
doaj +1 more source
Distribution patterns of tau pathology in progressive supranuclear palsy
Acta Neuropathologica, 2020 Progressive supranuclear palsy (PSP) is a 4R-tauopathy predominated by subcortical pathology in neurons, astrocytes, and oligodendroglia associated with various clinical phenotypes. In the present international study, we addressed the question of whether
G. Kovacs +22 more
semanticscholar +1 more source
, 2012 Tauopathies are age-related neurodegenerative diseases that are characterized by the presence of aggregates of abnormally phosphorylated tau. As tau was originally discovered as a microtubule-associated protein, it has been hypothesized that neurodegeneration results from a loss of the ability of tau to associate with microtubules.
Chad J. Leugers, Gloria Lee
openaire +3 more sources
The internal consistency of the goldberg questionnaire in farmers
INFAD, 2018 The General Health Questionnaire is used to detect the existence of a probable psychiatric disorder in the general population, among a community or in non-psychiatric settings, such as in public health or primary care (Pais Ribeiro, et al., 2015).
Cláudia Chaves +4 more
doaj +1 more source