Results 31 to 40 of about 212,588 (266)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Creatine transporter deficiency: Novel mutations and functional studies

Molecular Genetics and Metabolism Reports, 2016
X-linked cerebral creatine deficiency (MIM 300036) is caused by deficiency of the creatine transporter encoded by the SLC6A8 gene. Here we report three patients with this condition from Israel.
O. Ardon, M. Procter, R. Mao, N. Longo, Y.E. Landau, A. Shilon-Hadass, L.V. Gabis, C. Hoffmann, M. Tzadok, G. Heimer, S. Sada, B. Ben-Zeev, Y. Anikster   +12 more
doaj   +1 more source

Piecewise Affine Magnetic Modeling of Permanent-Magnet Synchronous Machines for Virtual-Flux Control

Energies, 2022
Accurate flux linkage magnetic models are essential for virtual-flux controllers in PMSMs. Flux linkage exhibits saturation and cross-saturation at high currents, introducing nonlinearities into the machine model.
Bernard Steyaert, Ethan Swint, W. Wesley Pennington, Matthias Preindl   +3 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Tau aggregation.

Histology and histopathology
Microtubule-associated protein tau is predominantly expressed in neurons in the form of multiple isoforms generated by alternative splicing. These isoforms differ in the presence of either three or four microtubule-binding repeats. These binding regions not only regulate tau's interaction with microtubules but are also critically involved in its ...
Domene-Serrano, Indalo, Santa-María, Ismael, Hernandez, Felix, Avila, Jesús   +3 more
openaire   +2 more sources

Tau and Tauopathies [PDF]

, 2012
Tauopathies are age-related neurodegenerative diseases that are characterized by the presence of aggregates of abnormally phosphorylated tau. As tau was originally discovered as a microtubule-associated protein, it has been hypothesized that neurodegeneration results from a loss of the ability of tau to associate with microtubules.
Gloria, Lee, Chad J, Leugers
openaire   +2 more sources

Diseñar con las manos. La relación entre el collage y el diseño gráfico

i + Diseño, 2019
Este artículo reflexiona acerca de las relaciones existentes entre el diseño gráfico y el collage, poniendo de relieve afinidades y diferencias en cuanto a metodología, procesos de trabajo y función.
Emilio Gil
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Measurements of the $\tau$ Mass and Mass Difference of the $\tau^{+}$ and $\tau^{-}$} at BaBar

, 2009
Comment: 15 pages, 10 figures, submitted to Phys.
B. Aubert, R. Barate, D. Boutigny, F. Couderc, Y. Karyotakis, J. P. Lees, V. Poireau, V. Tisserand, A. Zghiche, E. Grauges, A. Palano, M. Pappagallo, A. Pompili, J. C. Chen, N. D. Qi, G. Rong, P. Wang, Y. S. Zhu, G. Eigen, I. Ofte, B. Stugu, G. S. Abrams, M. Battaglia, A. B. Breon, D. N. Brown, J. Button Shafer, R. N. Cahn, M. S. Gill, A. V. Gritsan, Y. Groysman, R. G. Jacobsen, J. Kadyk, L. T. Kerth, Y.u. G. Kolomensky, G. Kukartsev, G. Lynch, L. M. Mir, P. J. Oddone, T. J. Orimoto, N. A. Roe, M. T. Ronan, W. A. Wenzel, M. Barrett, K. E. Ford, T. J. Harrison, A. J. Hart, C. M. Hawkes, B. Lewandowski, M. Pelizaeus, K. Peters, T. Schroeder, T. Cuhadar Donszelmann, B. G. Fulsom, C. Hearty, N. S. Knecht, T. S. Mattison, J. A. McKenna, A. Khan, P. Kyberd, M. Saleem, L. Teodorescu, A. E. Blinov, V. E. Blinov, A. D. Bukin, V. P. Druzhinin, V. B. Golubev, E. A. Kravchenko, A. P. Onuchin, S. I. Serednyakov, Y.u. I. Skovpen, E. P. Solodov, D. Best, M. Bondioli, M. Bruinsma, M. Chao, I. Eschrich, D. Kirkby, A. J. Lankford, M. Mandelkern, B. L. Hartfiel, S. D. Foulkes, J. W. Gary, O. Long, B. C. Shen, K. Wang, L. Zhang, D. del Re, H. K. Hadavand, E. J. Hill, D. B. MacFarlane, H. P. Paar, J. W. Berryhill, C. Campagnari, A. Cunha, M. A. Mazur, J. D. Richman, W. Verkerke, T. W. Beck, A. M. Eisner, C. J. Flacco, C. A. Heusch, J. Kroseberg, W. S. Lockman, G. Nesom, T. Schalk, B. A. Schumm, A. Seiden, P. Spradlin, D. C. Williams, M. G. Wilson, J. Albert, G. P. Dubois Felsmann, A. Dvoretskii, D. G. Hitlin, I. Narsky, T. Piatenko, F. C. Porter, A. Ryd, A. Samuel, R. Andreassen, S. Jayatilleke, G. Mancinelli, B. T. Meadows, M. D. Sokoloff, F. Blanc, P. Bloom, S. Chen, W. T. Ford, U. Nauenberg, A. Olivas, P. Rankin, W. O. Ruddick, J. G. Smith, K. A. Ulmer, S. R. Wagner, J. Zhang, A. Chen, E. A. Eckhart, A. Soffer, W. H. Toki, R. J. Wilson, Q. Zeng, D. Altenburg, E. Feltresi, A. Hauke, B. Spaan, T. Brandt, J. Brose, H. M. Lacker, R. Nogowski, S. Otto, A. Petzold, G. Schott, J. Schubert, K. R. Schubert, R. Schwierz, J. E. Sundermann, D. Bernard, G. R. Bonneaud, C.h. Thiebaux, G. Vasileiadis, M. Verderi, D. J. Bard, P. J. Clark, W. Gradl, F. Muheim, S. Playfer, Y. Xie, M. Andreotti, V. Azzolini, D. Bettoni, C. Bozzi, R. Calabrese, G. Cibinetto, E. Luppi, M. Negrini, L. Piemontese, F. Anulli, R. Baldini Ferroli, A. Calcaterra, R. de Sangro, G. Finocchiaro, P. Patteri, I. M. Peruzzi, M. Piccolo, A. Zallo, A. Buzzo, R. Capra, R. Contri, M. Lo Vetere, M. Macri, M. R. Monge, S. Passaggio, C. Patrignani, E. Robutti, A. Santroni, S. Tosi, S. Bailey, E. Won, J. Wu, N. Arnaud, F. Di Lodovico, P. S. Jackson, G. D. Lafferty, C. Chen, C. Dallapiccola, F. Palombo, C. Sciacca, G. Raven, J. Strube, J. Ocariz, G. Calderini, M. Carpinelli, G. Marchiori, N. Neri, C. Voena, T. Adye, G. Hamel de Monchenault, G. Vasseur, D. Su, M. Bomben, L. Lanceri, S.w. Banerjee, R. Kowalewski, J. M. Roney, T. E. Latham, S. L. Wu   +226 more
openaire   +3 more sources

Hypoxanthine Derivatives in Experimental Infections

Canadian Journal of Infectious Diseases, 1992
In vivo treatment with parenterally administered hypoxanthine derivatives, notably ST 789, was able to protect cyclophosphamide-immunosuppressed mice against experimental infections with both bacterial and fungal pathogens.
Claudio De Simone, Edoardo Arrigoni Martelli, Pietro Foresta, Giuseppe Famularo, Roberto Giacomelli, Emilio Jirillo, Vito Ruggiero, Giorgio Tonietti   +7 more
doaj   +1 more source