Results 11 to 20 of about 315,874 (315)
Frontiers in Aging Neuroscience, 2016 Tau is a microtubule-associated protein that plays an important role in axonal stabilization, neuronal development, and neuronal polarity. In this review, we focus on the primary, secondary, tertiary, and quaternary tau structures. We describe the structure of tau from its specific residues until its conformation in dimers, oligomers, and larger ...
Jesus Avila +9 more
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Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases [PDF]
Journal of Neurochemistry, 2009 AbstractTau is a neuronal microtubule‐associated protein. Its hyperphosphorylation plays a critical role in Alzheimer disease (AD). Expression and phosphorylation of tau are regulated developmentally, but its dynamic regulation and the responsible kinases or phosphatases remain elusive.
Yang, Yu +8 more
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Tau Pathology Generated by Overexpression of Tau [PDF]
The American Journal of Pathology, 1999 Neurofibrillary changes of abnormally hyperphosphorylated tau are the key lesion in Alzheimer’s disease (AD) and a number of other tauopathies. Recent developments in the field of autosomal dominantly inherited dementias, in particular the frontotemporal dementias and Parkinsonism linked to chromosome 17 (FTDP-17) group, have shown that abnormalities ...
I, Grundke-Iqbal, K, Iqbal
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Tau Aggregates and Tau Pathology
Journal of Alzheimer's Disease, 2008 There is controversy in some neurodegenerative disorders whether the presence of aberrant aggregates in a neuron could have a toxic or a protective effect. In some disorders like in encephalopathies (prion disease), protein aggregates are toxic for the neuron.
Hernández, Félix, Ávila, Jesús
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Frontiers in Aging Neuroscience, 2009 In this short review, I will focus on how a unique tau gene may produce many tau isoforms through alternative splicing and how the phosphorylation of these isoforms by different kinases may affect their activity and behaviour. Indeed, each of the different tau isoforms may play a distinct role under both physiological and pathological conditions. Thus,
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Neuroscience, 2023 Here we revisit tau protein aggregation at primary, secondary, tertiary and quaternary structures. In addition, the presence of non-aggregated tau protein, which has been recently discovered, is also commented on.
Hernández, Félix +5 more
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Tau here, tau there, tau almost everywhere: Clarifying the distribution of tau in the adult CNS
Cytoskeleton, 2023 AbstractThe microtubule‐associated protein tau has gained significant attention over the last several decades primarily due to its apparent role in the pathogenesis of several diseases, most notably Alzheimer's disease. While the field has focused largely on tau's potential contributions to disease mechanisms, comparably less work has focused on normal
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Nature Conservation Research: Заповедная наука, 2019 The Joint Directorate of the State Nature Reserves «Orenburg» and «Shaitan-Tau» (later – FSFI «Orenburg Reserves») elaborated the Programme on establishing a semi-free population of the Przewalski's horse in the Orenburg State Nature Reserve (Russia). It
Rafilia T. Bakirova +2 more
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Total and phosphorylated tau proteins: Evaluation as core biomarker candidates in frontotemporal dementia [PDF]
, 2004 An ever increasing number of patients with neurodegenerative disorders calls for the evaluation of potential diagnostic markers that allow an early diagnosis and an early initiation of specific therapy. Clinical diagnosis of Alzheimer's disease (AD), the
Teipel, S. J. +3 more
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Lepton and Photon Interactions at High Energies, 1992 16 pages, 8 figures. Invited talk at the XIX International Symposium on Lepton and Photon Interactions at High Energies (Stanford, August 1999)
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