Results 41 to 50 of about 168,002 (211)

Piecewise Affine Magnetic Modeling of Permanent-Magnet Synchronous Machines for Virtual-Flux Control

Energies, 2022
Accurate flux linkage magnetic models are essential for virtual-flux controllers in PMSMs. Flux linkage exhibits saturation and cross-saturation at high currents, introducing nonlinearities into the machine model.
Bernard Steyaert, Ethan Swint, W. Wesley Pennington, Matthias Preindl   +3 more
doaj   +1 more source

Amyloid and tau in the brain in sporadic Alzheimer’s disease: defining the chicken and the egg [PDF]

, 2014
In the October 2013 issue of Acta Neuropathologica there were three very interesting articles on: Amyloid or tau: the chicken or the egg? In the first article, David Mann and John Hardy argued that the deposition of aggregated amyloid β (Aβ) protein in ...
Cheryl A. Hawkes, Roy O. Weller, Roxana O. Carare, Hawkes, Cheryl A., Carare, Roxana O., Weller, Roy O.   +5 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Hypoxanthine Derivatives in Experimental Infections

Canadian Journal of Infectious Diseases, 1992
In vivo treatment with parenterally administered hypoxanthine derivatives, notably ST 789, was able to protect cyclophosphamide-immunosuppressed mice against experimental infections with both bacterial and fungal pathogens.
Claudio De Simone, Edoardo Arrigoni Martelli, Pietro Foresta, Giuseppe Famularo, Roberto Giacomelli, Emilio Jirillo, Vito Ruggiero, Giorgio Tonietti   +7 more
doaj   +1 more source

Effect of deuterium on the circadian period and metabolism in wild-type and tau mutant Syrian hamsters [PDF]

, 2000
Homozygous tau mutant Syrian hamsters (tau-/-) have a free-running circadian period (τ) around 20 h and a proportionally higher metabolic rate compared with wild-type hamsters (tau+/+) with a period of circa 24 h.
Malgorzata Oklejewicz, Daan, S, Hut, Roelof A.,, Hut, RA, Roelof A Hut, Serge Daan, Daan, Serge,, Oklejewicz, M, Oklejewicz, Malgorzata,   +8 more
core   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

LPS-induced serum TNF production and lethality in mice: effect of L-carnitine and some acyl-derivatives

Mediators of Inflammation, 1993
The effect of L-carnitine and some of its acyl derivatives on serum TNF production and lethality in a murine experimental endotoxin shock model was investigated. In some instances, serum IL-6 production was also evaluated.
Vito Ruggiero, Claudio M. D'Urso, Claudio Albertoni, Silvia Campo, Piero Foresta, Edoardo Arrigoni Martelli   +5 more
doaj   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

A interação argumentativa no discurso literário: da literatura das ideias ao relato de ficção

Linha D'Água, 2016
A dimensão argumentativa do texto literário se expressa na capacidade de orientar a visão de seus leitores. A teoria de Perelman inscreve a interação argumentativa no discurso do orador e os trabalhos contemporâneos em Linguística Pragmática e em ...
Ruth Amossy
doaj   +1 more source