Results 21 to 30 of about 46,807 (214)

Evaluation of taurine content on skeletal muscle of exercised rats using MALDI-TOF MS imaging analysis

Journal of Physical Fitness and Sports Medicine, 2020
The amount of taurine and taurine derivatives in the body is affected by various diseases and physiological events, such as exercise. However, there is little information about possible changes in taurine distribution within tissue. In the present study,
Riho Komatsuzawa, Teruo Miyazaki, Hajime Ohmori, Chitose Maruyama, Stephen W. Schaffer, Shigeru Murakami, Takashi Ito   +6 more
doaj   +1 more source

Taurine: a promising nutraceutic in the prevention of retinal degeneration

Neural Regeneration Research
Taurine is considered a non-essential amino acid because it is synthesized by most mammals. However, dietary intake of taurine may be necessary to achieve the physiological levels required for the development, maintenance, and function of certain tissues.
Diego García-Ayuso, Johnny Di Pierdomenico, Ana Martínez-Vacas, Manuel Vidal-Sanz, Serge Picaud, María P Villegas-Pérez   +5 more
doaj   +1 more source

Involvement of TauT/SLC6A6 in Taurine Transport at the Blood–Testis Barrier

Metabolites, 2022
Taurine transport was investigated at the blood–testis barrier (BTB) formed by Sertoli cells. An integration plot analysis of mice showed the apparent influx permeability clearance of [3H]taurine (27.7 μL/(min·g testis)), which was much higher than that ...
Yoshiyuki Kubo, Sakiko Ishizuka, Takeru Ito, Daisuke Yoneyama, Shin-ichi Akanuma, Ken-ichi Hosoya   +5 more
doaj   +1 more source

Taurine provides neuroprotection against retinal ganglion cell degeneration. [PDF]

PLoS ONE, 2012
Retinal ganglion cell (RGC) degeneration occurs in numerous retinal diseases leading to blindness, either as a primary process like in glaucoma, or secondary to photoreceptor loss.
Nicolas Froger, Lucia Cadetti, Henri Lorach, Joao Martins, Alexis-Pierre Bemelmans, Elisabeth Dubus, Julie Degardin, Dorothée Pain, Valérie Forster, Laurent Chicaud, Ivana Ivkovic, Manuel Simonutti, Stéphane Fouquet, Firas Jammoul, Thierry Léveillard, Ryad Benosman, José-Alain Sahel, Serge Picaud   +17 more
doaj   +1 more source

Regulation of taurine transport at the blood-placental barrier by calcium ion, PKC activator and oxidative stress conditions

Journal of Biomedical Science, 2010
Background In the present study, we investigated the changes of uptake and efflux transport of taurine under various stress conditions using rat conditionally immortalized syncytiotrophoblast cell line (TR-TBT cells), as in vitro blood-placental barrier (
Lee Na-Young, Kang Young-Sook
doaj   +1 more source

Taurine ameliorates cellular senescence associated with an increased hydrogen sulfide and a decreased hepatokine, IGFBP-1, in CCl4-induced hepatotoxicity in mice

Redox Biology
This study investigated the protective effects of taurine against cellular senescence and hepatokine secretion in a mouse model of carbon tetrachloride (CCl4)-induced chronic liver injury.
Akihiro Tsuboi, Hamida Khanom, Riki Kawabata, Takanori Matsui, Shigeru Murakami, Takashi Ito   +5 more
doaj   +1 more source

Taurine Alleviates the Progression of Diabetic Nephropathy in Type 2 Diabetic Rat Model

International Journal of Endocrinology, 2014
The overexpression of vascular endothelial growth factor (VEGF) is known to be involved in the pathogenesis of diabetic nephropathy. In this study, the protective effects of taurine on diabetic nephropathy along with its underlying mechanism were ...
Jang Hyun Koh, Eun Soo Lee, Miri Hyun, Hong Min Kim, Yoon Jung Choi, Eun Young Lee, Dhananjay Yadav, Choon Hee Chung   +7 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source