Results 31 to 40 of about 63,418 (298)

Taurine ameliorates cellular senescence associated with an increased hydrogen sulfide and a decreased hepatokine, IGFBP-1, in CCl4-induced hepatotoxicity in mice

Redox Biology
This study investigated the protective effects of taurine against cellular senescence and hepatokine secretion in a mouse model of carbon tetrachloride (CCl4)-induced chronic liver injury.
Akihiro Tsuboi, Hamida Khanom, Riki Kawabata, Takanori Matsui, Shigeru Murakami, Takashi Ito   +5 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Second‐Sphere Aromatic Substitutions That Tune H‐Atom Transfer Reactivity Observed for a Series of S = 1 Nonheme FeIV=O Complexes: An Enthalpy‐Entropy Compensation Effect

Angewandte Chemie, EarlyView.
A series of oxoiron(IV) complexes was synthesized to determine the impact of electronically tuned aromatic substitution in the secondary sphere of the ligand. Despite possessing identical electronic properties, they show significant differences in C─H oxidation reactions.
Abhishek Das, Jin Xiong, Victor G. Young Jr., Yisong Guo, Marcel Swart, Lawrence Que Jr.   +5 more
wiley   +2 more sources

Taurine Alleviates the Progression of Diabetic Nephropathy in Type 2 Diabetic Rat Model

International Journal of Endocrinology, 2014
The overexpression of vascular endothelial growth factor (VEGF) is known to be involved in the pathogenesis of diabetic nephropathy. In this study, the protective effects of taurine on diabetic nephropathy along with its underlying mechanism were ...
Jang Hyun Koh, Eun Soo Lee, Miri Hyun, Hong Min Kim, Yoon Jung Choi, Eun Young Lee, Dhananjay Yadav, Choon Hee Chung   +7 more
doaj   +1 more source

Chronic cocaine enhances release of neuroprotective amino acid taurine: a microdialysis study [PDF]

, 2008
Cocaine inhibits high-affinity neurotransmitter uptake at the presynaptic nerve terminals to increase synaptic levels of dopamine, norepinephrine and serotonin^1^. This increase of synaptic dopamine may cause neurotoxicity^2,3^.
Theodore Lidsky, Shailesh Banerjee, Elena Yablonski-Alter, Eleonora Gashi, Mervan Agovic, Eitan Freedman   +5 more
core  

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Effect of Taurine and Hypotaurine on Mouse Embryo Development [PDF]

, 1995
To investigate the effect of taurine and hypotaurine on the in vitro development of mouse embryos from 1-cell to blastocyst, the embryos were incubated in four media, i.e., M16, M16 plus EDTA, M16 plus taurine and M16 plus hypotaurine.The incorporation ...
Nakano, M, Tsujii, H
core  

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Electrochemical Preparation and Characterization of Gold and Platinum Nanoparticles Modified Poly(taurine) Film Electrode and Its Application to Hydrazine Determination

International Journal of Electrochemical Science, 2016
A highly sensitive hydrazine sensor has been developed by using gold and platinum nanoparticles (NPs) decorated poly(taurine) on modified glassy carbon electrode (GCE).
Çağrı Ceylan Koçak, Aylin Altın, Burak Aslışen, Süleyman Koçak   +3 more
doaj   +1 more source

Deterioration of Traditional Dietary Custom Increases the Risk of Lifestyle-Related Diseases in Young Male Africans. [PDF]

, 2010
Prevalence of metabolic syndrome (MS) is rapidly increasing worldwide. To investigate the spread of MS risks and its relationship with eating habits including fish intake, we carried out a health examination for young and middle-aged men.
Hamada, Atsumi, Mori, Hideki, Atsumi Hamada, Marina Njelekela, Zablon Masesa, Hideki Mori, Mori, Mari, Mari Mori, Njelekela, Marina, Mtabaji, Jacob, Jacob Mtabaji, Yukio Yamori, Yamori, Yukio, Alfa Muhihi, Masesa, Zablon, Muhihi, Alfa   +15 more
core   +1 more source