Results 151 to 160 of about 3,819 (214)

Similarity‐Enhanced Representation Learning of Non‐Canonical Amino Acids for Therapeutic Peptide Modeling

Advanced Science, EarlyView.
Non‐canonical amino acids (ncAAs) enhance peptide therapeutics but remain difficult to model computationally. SinCAA, a similarity‐enhanced pretraining framework, jointly optimizes contrastive learning guided by a novel conformational similarity metric with masked node reconstruction, capturing both functional relationships and chemical identity of ...
Chencheng Xu, Lesong Wei, Jianmin Wang, Yuanpeng Xiong, Ruochi Zhang, Yu Wang, Chao Zha, Qiangcheng Zeng, Xin Gao   +8 more
wiley   +1 more source

Erratum: Peripheral Measurable Residual Disease Activity Assessment by MALDI-TOF Mass Spectrometry in Patients With Newly Diagnosed Multiple Myeloma in the Phase III GMMG-HD7 Trial. [PDF]

J Clin Oncol
Jin JX, Ginde VR, Huhn S, Reichert P, Bertsch U, Fenk R, Besemer B, Boquoi A, Schroers R, von Metzler I, Hänel M, Mann C, Leypoldt LB, Heilmeier B, Scheid C, Peters-Regehr T, Blau IW, Müller-Tidow C, Luntz S, Holderried TAW, Trautmann-Grill K, Gezer D, Klaiber-Hakimi M, Müller M, Shumilov E, Knauf W, Michel CS, Geer T, Riesenberg H, Lutz C, Raab MS, Weinhold N, Hoffmann M, Benner A, Findeisen P, Weisel KC, Salwender HJ, Mai EK, Goldschmidt H, German-Speaking Myeloma Multicenter Group (GMMG) HD7 Investigators.   +39 more
europepmc   +1 more source

MethyAnno: An Interpretable Automated Annotation Method Leveraging Multi‐Scale Information and Metric Learning Framework for scDNAm Data

Advanced Science, EarlyView.
MethyAnno enables robust and interpretable annotation of single‐cell DNA methylation data by integrating multi‐scale epigenetic information, bidirectional cross‐attention, and prototype‐based metric learning. The framework resolves rare and novel cell types across datasets while revealing cell‐type‐specific epigenetic signatures associated with disease
Yuhang Jia, Siyu Li, Songming Tang, Keju Gu, Shengquan Chen   +4 more
wiley   +1 more source

Enhancing wheat drought resilience through organic amendments: integrating soil health improvement and antioxidant defense activation. [PDF]

BMC Plant Biol
Sohail S, Chenyun B, Hanyang T, Khosa SY, Ali MF, Abbas MM, Ahamd ST, Iqbal M, Xiaoyang H, Yuanjun Z.   +9 more
europepmc   +1 more source

Single‐Molecule Imaging of Endogenous RNA Using a Miniaturized and Circularly Permuted CRISPR‐Cas13 Degron‐Masking System CDegSR

Advanced Science, EarlyView.
CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley   +1 more source

Transformer-based models for ADR detection: cross-drug validation and benchmarking against large language models. [PDF]

Ther Adv Drug Saf
Kim M, Kim KE, Kwon JH, Han JY, Kim JH, Kim MG.   +5 more
europepmc   +1 more source

Multifunctional Quantum Sensing Using Single Spins in a van der Waals Crystal

Advanced Science, EarlyView.
The work demonstrates a dual quantum sensing of temperature and magnetic field using spin‐complex quantum emitters in hexagonal boron nitride (hBN). Temperature sensing via zero‐phonon‐line shifts and magnetometry via optically detected magnetic resonances, enable simultaneous local thermometry and magnetic‐field measurements.
James Liddle‐Wesolowski, Konosuke Shimazaki, Jiyun Kim, Benjamin Whitefield, Kenji Watanabe, Takashi Taniguchi, Mehran Kianinia, Igor Aharonovich   +7 more
wiley   +1 more source

First genomic evidence and molecular epidemiology of porcine bufavirus in Myanmar: Whole-genome characterization, phylogenetic insights, and potential zoonotic implications. [PDF]

Vet World
Phyu HW, Charoenkul K, Nasamran C, Udom K, Phyu EM, Thaw YN, Chaiyawong S, Lin TN, Maw MT, Amonsin A.   +9 more
europepmc   +1 more source

Longitudinal Multifrequency MR Elastography Reveals Biomechanical Signatures of Progression in a Translational Liver Tumor Model

Advanced Science, EarlyView.
Longitudinal multifrequency magnetic resonance elastography (mMRE) performed on a clinical 3 Tesla magnetic resonance imaging system reveals early biomechanical alterations during liver tumor progression in a translational VX2 model. Changes in tumor stiffness and viscosity precede diffusion‐related alterations and are associated with extracellular ...
Justus Ramtke, Friederike Hesse, Lasse Noack, Justus Klockner, Yubei He, Yu Liu, Yanglei Wu, Robin Schmidt, Selma Saclier, Salma A. S. Abosabie, Tom Meyer, Richard Ruppel, Nikolaus Berndt, Michael Mülleder, Eyk Schellenberger, Nicola Beindorff, Dominik N. Müller, Ingolf Sack, Jing Guo, Shraga Nahum Goldberg, Lynn Jeanette Savic   +20 more
wiley   +1 more source

Evaluating accessibility of e-health websites in Indonesia: Bridging the digital divide for people with disabilities. [PDF]

J Educ Health Promot
Hafiar H, Risanti YD, Nurfadila F, Ratnasari E, Dipa AK, Nasrullah R, Safi AQ.   +6 more
europepmc   +1 more source