Results 211 to 220 of about 64,747 (267)
The alpha tubulin acetyltransferase <i>atat-2</i> genetically interacts with <i>klp-4</i> in <i>C. elegans</i>. [PDF]
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Journal of Pediatric Oncology Nursing, 1993
Taxol is a novel antineoplastic agent that has demonstrated significant activity in ovarian carcinoma. Clinical trials are now underway to determine its use in combination with other chemotherapeutic agents, cytokines, and other cancers. The purpose of this article is to review clinical trials using Taxol and relevant nursing care for patients ...
D L, Betcher, N, Burnham
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Taxol is a novel antineoplastic agent that has demonstrated significant activity in ovarian carcinoma. Clinical trials are now underway to determine its use in combination with other chemotherapeutic agents, cytokines, and other cancers. The purpose of this article is to review clinical trials using Taxol and relevant nursing care for patients ...
D L, Betcher, N, Burnham
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Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1994
Paclitaxel is a novel antineoplastic that effects cytotoxicity by promoting intracellular tubulin polymerization and stabilizes abnormal microtubule structures against depolymerization. Although its clinical development had been hampered by misconceptions about its pharmacology, its scarcity, difficulties extracting it from its natural source ...
D R, Kohler, B R, Goldspiel
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Paclitaxel is a novel antineoplastic that effects cytotoxicity by promoting intracellular tubulin polymerization and stabilizes abnormal microtubule structures against depolymerization. Although its clinical development had been hampered by misconceptions about its pharmacology, its scarcity, difficulties extracting it from its natural source ...
D R, Kohler, B R, Goldspiel
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Chemotherapy, 2000
<i>Background:</i> Taxol has gained considerable attention in cancer therapy in recent years and is successfully used in treating a variety of tumors, including those of the breast, ovary and lung. Despite its preclinical and clinical success, the ability of tumors to develop an acquired resistance to drugs used for treatment remains a ...
S, Sangrajrang, A, Fellous
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<i>Background:</i> Taxol has gained considerable attention in cancer therapy in recent years and is successfully used in treating a variety of tumors, including those of the breast, ovary and lung. Despite its preclinical and clinical success, the ability of tumors to develop an acquired resistance to drugs used for treatment remains a ...
S, Sangrajrang, A, Fellous
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Phytochemistry, 2001
The function and properties of heterologously expressed full-length cDNA clones, isolated from a Taxus cDNA library and specific to Taxol biosynthesis, are summarized. Recombinant enzymes are described that catalyze early steps of the pathway, including taxadiene synthase, taxadien-5alpha-ol-O-acetyltransferase and taxadien-5alpha-yl acetate 10beta ...
K, Walker, R, Croteau
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The function and properties of heterologously expressed full-length cDNA clones, isolated from a Taxus cDNA library and specific to Taxol biosynthesis, are summarized. Recombinant enzymes are described that catalyze early steps of the pathway, including taxadiene synthase, taxadien-5alpha-ol-O-acetyltransferase and taxadien-5alpha-yl acetate 10beta ...
K, Walker, R, Croteau
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Applied Biochemistry and Biotechnology, 1995
Taxol® (paclitaxel) has been hailed by many as the most promising new cancer treatment in two decades. The FDA requires that paclitaxel intended for human consumption be obtained only from the bark of Taxus brevifolia, the Pacific yew. As this may become increasingly uneconomical, new strategies must be explored to ensure the continued availability of ...
Dean P. Stull +4 more
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Taxol® (paclitaxel) has been hailed by many as the most promising new cancer treatment in two decades. The FDA requires that paclitaxel intended for human consumption be obtained only from the bark of Taxus brevifolia, the Pacific yew. As this may become increasingly uneconomical, new strategies must be explored to ensure the continued availability of ...
Dean P. Stull +4 more
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Nature, 1994
Taxol, a substance originally isolated from the Pacific yew tree (Taxus brevifolia) more than two decades ago, has recently been approved for the clinical treatment of cancer patients. Hailed as having provided one of the most significant advances in cancer therapy, this molecule exerts its anticancer activity by inhibiting mitosis through enhancement ...
K. C. Nicolaou +10 more
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Taxol, a substance originally isolated from the Pacific yew tree (Taxus brevifolia) more than two decades ago, has recently been approved for the clinical treatment of cancer patients. Hailed as having provided one of the most significant advances in cancer therapy, this molecule exerts its anticancer activity by inhibiting mitosis through enhancement ...
K. C. Nicolaou +10 more
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Annual Review of Plant Physiology and Plant Molecular Biology, 1994
P F Heinstein, C J Chang
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P F Heinstein, C J Chang
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Journal of Medicinal Chemistry, 2006
T-Taxol is a proposal for the bioactive conformation of paclitaxel (PTX) derived from fitting ligand conformations to the electron crystallographic (EC) density. Although confirmed by a number of studies, some structural ambiguities based on the interpretation of two solid-state REDOR (13)C-(19)F distances in a fluorinated PTX derivative remain.
Ana A, Alcaraz +3 more
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T-Taxol is a proposal for the bioactive conformation of paclitaxel (PTX) derived from fitting ligand conformations to the electron crystallographic (EC) density. Although confirmed by a number of studies, some structural ambiguities based on the interpretation of two solid-state REDOR (13)C-(19)F distances in a fluorinated PTX derivative remain.
Ana A, Alcaraz +3 more
openaire +2 more sources