Results 191 to 200 of about 69,416 (282)

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding   +4 more
wiley   +1 more source

Anaerobic Attenuation of Diisopropyl Ether (DIPE) in Groundwater: Kinetics and Implications for Monitored Natural Attenuation

open access: yesGroundwater Monitoring &Remediation, EarlyView.
Abstract Diisopropyl ether (DIPE) is a branched ether used as a solvent, extractant, and gasoline additive. While aerobic biodegradation of DIPE has been documented, attenuation under anaerobic conditions (typical of groundwater impacted by petroleum hydrocarbons and fuel oxygenates) remains poorly constrained.
Sandra Dworatzek   +11 more
wiley   +1 more source

Serum Redox Biomarkers in Canine Mast Cell Tumors: Exploratory Associations with Proliferative Activity and Clinicopathological Features. [PDF]

open access: yesAntioxidants (Basel)
Ginoudis A   +6 more
europepmc   +1 more source

Cisterna Chyli Dilation Is a Risk Factor for Liver Nodules and Hepatocellular Carcinoma in Fontan‐Associated Liver Disease: Pathophysiological Role of Lymphatic Dysfunction

open access: yesHepatology Research, EarlyView.
ABSTRACT Aim In Fontan‐associated liver disease (FALD), chronic congestion often confounds conventional fibrosis markers, complicating surveillance for hepatocellular carcinoma (HCC). Although lymphatic dysfunction is fundamental to Fontan physiology, its contribution to hepatocarcinogenesis remains unclear.
Koji Imoto   +14 more
wiley   +1 more source

Continuous Distillation for Drug Substance Manufacturing. [PDF]

open access: yesPharm Res
Penzer KE   +5 more
europepmc   +1 more source

Epigenetic and Metabolic Changes That Drive Trained Immunity in Response to Microbes and Vaccines

open access: yesImmunology, EarlyView.
This graphical abstract illustrates how microbial products, vaccines and microbial metabolites activate pattern‐recognition receptor signalling, inducing metabolic rewiring and epigenetic remodelling. These changes establish long‐lasting trained immunity through the functional reprogramming of haematopoietic progenitors and innate immune cells, thereby
Desalegn Abebaw   +10 more
wiley   +1 more source

Light-Controlled Folding and Chiroptical Sensing of G-Quadruplex DNA. [PDF]

open access: yesJ Phys Chem Lett
Matusiak A   +4 more
europepmc   +1 more source

Superior classification of visuospatial neglect in the subacute phase through free‐viewing and considering overcompensation

open access: yesJournal of Neuropsychology, EarlyView.
Abstract Visuospatial neglect is a common disorder of spatial attention after stroke. Traditional paper‐and‐pencil tasks are widely used for diagnosis but show limited sensitivity in the subacute phase, partly due to compensatory and (over)compensatory strategies.
T. L. G. Hamers   +3 more
wiley   +1 more source

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