Results 121 to 130 of about 5,428 (208)

Tbx1regulates extracellular matrix-cell interactions in the second heart field

, 2018
SUMMARYTbx1,the major candidate gene for DiGeorge or 22q11.2 deletion syndrome, is required for efficient incorporation of cardiac progenitors (CPs) of the second heart field (SHF) into the heart.
Marchesa Bilio, Daniela Alfano, Claudio Cortes, Antonio Baldini, Alessandra Altomonte, Robert G. Kelly   +5 more
core   +1 more source

NK4 contributes to restricting Tbx1/10 expression to the ASM precursors.

, 2013
(A–D, I–K and Q–S) Tbx1/10 mRNAs (green), (E–H, M–P) Tbx1/10 nascent transcripts (green) and (Q–S) COE mRNA (blue). Larvae electroporated with Mesp>nls:lacZ (red), FoxF>mCherry (I, M and O), FoxF>dnNK4 (J, N and P), and FoxF>NK4 (K).
Alexandra Ketcham (492291), Wei Wang (17594), Eric Siu (318570), Florian Razy-Krajka (492290), Lionel Christiaen (250348)   +4 more
core   +1 more source

In-silico identification of deleterious non-synonymous SNPs of TBX1 gene: Functional and structural impact towards 22q11.2DS.

PLoS ONE
The TBX1 gene plays a critical role in the development of 22q11.2 deletion syndrome (22q11.2DS), a complex genetic disorder associated with various phenotypic manifestations.
Maitha Almakhari, Yan Chen, Amanda Shen-Yee Kong, Danesh Moradigaravand, Kok-Song Lai, Swee-Hua Erin Lim, Jiun-Yan Loh, Sathiya Maran   +7 more
doaj   +1 more source

Differentiation assay of the mES-Tbx1Tet^OFF cell line.

, 2015
A: Scheme of experimental protocol. B: qRT-PCR assay of Tbx1 expression in uninduced (+Tet) mES-Tbx1Tet OFF cells. A peak of expression is evident at day 6. C: Schematic representation of the experimental strategy used for pulse Tbx1 expression.
Rosa Ferrentino (177859), Gabriella Lania (797696), Antonio Baldini (177873)   +2 more
core   +1 more source

Tbx1 regulates extracellular matrix-cell interactions in the second heart field

, 2019
Tbx1, the major candidate gene for DiGeorge or 22q11.2 deletion syndrome, is required for efficient incorporation of cardiac progenitors of the second heart field (SHF) into the heart.
Alfano D., Kelly, Robert,, Baldini, Antonio, Cortes C., Bilio, Marchesa, Kelly, Robert, G., Altomonte A., Baldini A., Bilio M., Kelly R. G., Cortes, Claudio, Alfano, Daniela, Altomonte, Alessandra   +12 more
core   +1 more source

TBX1 Gene [PDF]

, 2020
openaire   +1 more source

Tbx1^−/−;Wnt5a^−/− embryos have severe cardiac abnormalities.

, 2012
(A–D′) Whole mount histology study showed reduced overall size of Tbx1−/−; Wnt5a−/− embryos at E9.5 (n = 10), compared with control (WT), Tbx1−/− or Wnt5a−/− littermates.
Li Chen (5749), Rosa Ferrentino (177859), Stefania Martucciello (177865), Elizabeth A. Illingworth (177870), Antonio Baldini (177873), Filomena Gabriella Fulcoli (177854)   +5 more
core   +1 more source

Tbx1: potential targets and interactors relevant to development of structures affected in DiGeorge Syndrome [PDF]

, 2010
22q11DS is the most common microdeletion syndrome in humans, causing a range of phenotypes associated with abnormal pharyngeal development. TBX1 is considered the major genetic determinant of the syndrome. Deletion of Tbx1 in animal models phenocopies
Papangeli, I.
core  

Tbx1 stabilizes differentiation of the cardiopharyngeal mesoderm and drives morphogenesis in the pharyngeal apparatus

: TBX1, a T-box transcription factor, is essential for pharyngeal apparatus development and marks cardiopharyngeal mesoderm (CPM) in various species.
Baldini, Antonio, Lanzetta, Olga, Jechow, Katharina, Wei Ten, Foo, Ferrentino, Rosa, Liebig, Johannes, Bilio, Marchesa, Angelini, Claudia, Conrad, Christian, Lukassen, Soeren, Aurigemma, Ilaria, Illingworth, Elizabeth   +11 more
core   +1 more source

TBX1 wt Allele [PDF]

, 2020
openaire   +1 more source