Results 81 to 90 of about 86,653 (265)
Advanced Science, EarlyView.A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang +12 more
wiley +1 more source
Proteogenomic characterization of cholangiocarcinoma
Hepatology, EarlyView., 2022 Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng +18 more
wiley +1 more source
Impact of ICD-11 Inclusion of TCM Codes on the Global Burden of Disease [PDF]
Zhongguo quanke yixueBurden of disease measurement based on the International Statistical Classification of Diseases and Related Health Problems (ICD) codes have been widely used worldwide. However, most of the current studies are based on Western medical codes of ICD.
ZHOU Jingjing, HE Kaiyue, LIU Ailing, ZHAO Lanhui, GAO Jing, ZHOU Shangcheng
doaj +1 more source
Study on the Setting of TCM Curriculums for Undergraduate Nursing Profession in TCM Universities
DEStech Transactions on Social Science, Education and Human Science, 2019 The setting of the main TCM curriculums in the undergraduate nursing profession of TCM colleges and universities is directly related to the realization of the characteristics of TCM nursing education. In this paper, the horizontal contrast analysis method is used to visualize the main curriculum materials of the undergraduate nursing profession of 24 ...
Hong-ying WANG +3 more
openaire +2 more sources
Bistable Networks Enable Complex Shape Changes
Advanced Science, EarlyView.Transition‐controlled metamaterials are networks of bistable mechanical memory that store local binary states and express them as global shape change. By decoupling low‐force programming from high‐force holding, a single lattice is reconfigured into distinct 2D profiles and 3D surfaces without continuous actuation, enabling reusable morphing materials ...
Sawyer Thomas, Jeffrey Lipton
wiley +1 more source
Advanced Science, EarlyView.Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa +11 more
wiley +1 more source
Nanometer Layer Coating to Lactose Particles for Optimization of Dexamethasone Pulmonary Delivery
Advanced Science, EarlyView.Nanometer layer coating (NLC) was investigated and its mechanism illustrated by advanced characterization techniques. The effects and application for the inhalation of dexamethasone (DEX) were demonstrated through in vitro and in vivo evaluation. This approach increased DEX bioavailability and enabled the dose to be reduced to 1/30 of the intravenous ...
Qin Nie +11 more
wiley +1 more source
Advanced Science, EarlyView.FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin +9 more
wiley +1 more source
Frontiers in Public HealthBackgroundThis study investigates the relationship between TCM bitterness perception and individuals’ intention to use traditional Chinese medicine (TCM), employing the ‘stimuli–organism–response’ (SOR) framework.
Guoqing Wang +11 more
doaj +1 more source