Results 61 to 70 of about 103,235 (308)

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Qici Sanling decoction suppresses bladder cancer growth by inhibiting the Wnt/Β-catenin pathway

Pharmaceutical Biology, 2019
Context: Bladder cancer, which has high recurrence, is one of the most deadly cancers in the world. Astragalus propinquus Schischkin (Fabaceae) and Sagittaria sagittifolia L.
Hua Gong, Weihua Chen, Lanhua Mi, Dan Wang, Youkang Zhao, Chao Yu, Aiguang Zhao   +6 more
doaj   +1 more source

Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis-0

, 2011
Copyright information:Taken from "Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis"http://www.translational-medicine.com/content/5/1 ...
Mary Sullivan-Whalen (76199), Michelle A Lowes (76204), Shao-Lee Lin (76195), Irma Cardinale (76200), Knut M Wittkowski (27736), Toyoko Kikuchi (76197), Patricia Gilleaudeau (76198), Francesca Chamian (76194), Artemis Khatcherian (76201), Edmund Lee (76196), Inna Novitskaya (76202), James G Krueger (76203)   +11 more
core   +1 more source

Table2_AGREE II for TCM: Tailored to evaluate methodological quality of TCM clinical practice guidelines.docx

, 2023
Background: The Appraisal of Guidelines Research and Evaluation (AGREE) II instrument has been widely used in the methodological quality assessment of clinical practice guidelines (CPG). Chinese medicine CPGs have unique characteristics which distinguish
Yangyang Wang (642852), Xiuli Xie (5144024), Hui Li (32376)   +2 more
core   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Insights on the development of TCM nursing

, 2016
BackgroundTraditional Chinese medicine nursing (TCM nursing) is one of the highlights of nursing profession in China, which plays a significant role in Chinese healthcare system. However, bottlenecks exist in TCM nursing development.
Sun, Ying, Jun-Qiang Zhao, Adler-Collins, Je Kan, Ying Sun, Yu-Fang Hao, Run-Xi Tian, Tian, Run-Xi, Hao, Yu-Fang, Zhou, Fen, Je Kan Adler-Collins, Zhao, Jun-Qiang, Fen Zhou   +11 more
core   +1 more source

Table3_AGREE II for TCM: Tailored to evaluate methodological quality of TCM clinical practice guidelines.DOCX

, 2023
Background: The Appraisal of Guidelines Research and Evaluation (AGREE) II instrument has been widely used in the methodological quality assessment of clinical practice guidelines (CPG). Chinese medicine CPGs have unique characteristics which distinguish
Yangyang Wang (642852), Xiuli Xie (5144024), Hui Li (32376)   +2 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Modulating the tumor microenvironment: The role of traditional Chinese medicine in improving lung cancer treatment

Open Life Sciences
The holistic approach of traditional Chinese medicine (TCM) has been increasingly being focused on as a potential adjuvant to conventional lung cancer therapies in an attempt at modulating the tumor microenvironment (TME).
Teng Geling, Zhang Min, Pan Yuling, Karampoor Sajad, Mirzaei Rasoul   +4 more
doaj   +1 more source

Clinical Effect of Electroacupuncture on Acute Pancreatitis: Efficacies and Mechanisms

Journal of Inflammation Research, 2023
Xianqiang Yu,1,2 Qian Zhu3 1Women and Children’s Hospital Affiliated to Qingdao University, Qingdao, People’s Republic of China; 2University of California, Los Angeles, Department of Cardiology, Los Angeles, CA, USA; 3Department of Hepatobiliary Surgery,
Yu X, Zhu Q
doaj