Results 41 to 50 of about 117,722 (300)

Bistable Networks Enable Complex Shape Changes

Advanced Science, EarlyView.
Transition‐controlled metamaterials are networks of bistable mechanical memory that store local binary states and express them as global shape change. By decoupling low‐force programming from high‐force holding, a single lattice is reconfigured into distinct 2D profiles and 3D surfaces without continuous actuation, enabling reusable morphing materials ...
Sawyer Thomas, Jeffrey Lipton
wiley   +1 more source

Chinese Medical Injections for Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Network Meta-analysis

International Journal of COPD, 2021
Haiyin Hu,1,* Zhaochen Ji,1,* Xiaoyu Qiang,1 Shigang Liu,2 Xiaodi Sheng,1 Zhe Chen,1 Fanqi Liu,3 Hui Wang,1 Junhua Zhang1 1Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China ...
Hu H, Ji Z, Qiang X, Liu S, Sheng X, Chen Z, Liu F, Wang H, Zhang J   +8 more
doaj  

HMGA1 Promotes Macrophage Recruitment via Activation of NF-κB-CCL2 Signaling in Hepatocellular Carcinoma

Journal of Immunology Research, 2022
Background. Tumor-associated macrophages (TAMs) are known to generate an immune-suppressive tumor microenvironment (TME) and promote tumor progression.
Junming Chen, Kang Ji, Lingyan Gu, Yu Fang, Ming Pan, Shuxia Tian   +5 more
doaj   +1 more source

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Concatenated Space Time Block Codes and TCM, Turbo TCM Convolutional as well as Turbo Codes

, 2000
Space-time block codes provide substantial diversity advantages for multiple transmit antenna systems at a low decoding complexity. In this paper, we concatenate space-time codes with Convolutional Codes (CC), Turbo Convolutional codes (TC), Turbo BCH ...
Pliquett, J., Yeap, B.L., Liew, T.H., Yang, L-L., Hanzo, L.   +4 more
core   +1 more source

The Comorbidities, CHA2DS2-Vasc Scores, and Complications between the TCM and Non-TCM Groups.

, 2016
The Comorbidities, CHA2DS2-Vasc Scores, and Complications between the TCM and Non-TCM Groups.
Chih-Hsin Muo (291210), Chun-Ting Liu (1881562), Hsienhsueh Elley Chiu (515375), Yu-Chiang Hung (381915), Wen-Long Hu (646310), Yu-Chen Cheng (3153366)   +5 more
core   +1 more source

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Advanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan, Peiyi Li, Yufeng Chen, Zishan Dong, Yuanyuan Li, Boyu Liu, Yan Tai, Chuan Wang, Jianqiao Fang, Chengyu Yin, Boyi Liu   +10 more
wiley   +1 more source

DCABM-TCM: A Database of Constituents Absorbed into the Blood and Metabolites of Traditional Chinese Medicine

, 2023
Traditional Chinese medicine (TCM) not only maintains the health of Asian people but also provides a great resource of active natural products for modern drug development.
Ruzhen Chen, Lin Xing (7384631), Xuetai Chen (2447773), Yaning Qi (2340709), Runa Li, Yaning Qi, Honglei Li (350859), Zhongyang Liu (1863094), Honglei Li, Jiachen Guo, Feifei Guo (529728), Liying Yuan (14683906), Biyue Yu, Jinying Liu (2391718), Jiachen Guo (5005130), Runa Li (14683903), Dong Li, Jing Zhang (23775), Shuzhen Guo (112140), Xuetai Chen, Bangze Fu, Ruzhen Chen (12894956), Yuan Liu, Zhongyang Liu, Shuzhen Guo, Feng Xu (89016), Jing Zhang, Xinyue Liu (170148), He Chen, Dong Li (212687), Xinyue Liu, Jianzhou Jiang, Feng Xu, Lin Xing, Yuan Liu (88411), He Chen (104732), Biyue Yu (14683912), Liying Yuan, Bangze Fu (14683915), Jianzhou Jiang (16641198), Feifei Guo, Jinying Liu   +41 more
core   +3 more sources

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

Effects of TCMs and Lactobacillus strains on immunosuppressed mice and bacteriostatic effect on Escherichia coli K88 after fermentation

Biotechnology & Biotechnological Equipment, 2019
The aim of this study was to investigate a novel means of treating piglet diarrhoea caused by enterotoxigenic Escherichia coli (ETEC) strain K88 using traditional Chinese medicine (TCM) fermented by selected probiotic strains.
Wei Gu, Mingjie Sun, Wentao Yang, Lirong Wang, Yanlong Jiang, Chunfeng Wang, Guilian Yang   +6 more
doaj   +1 more source