Results 51 to 60 of about 103,235 (308)

Obese rats intervened with Rhizoma coptidis revealed differential gene expression and microbiota by serum metabolomics

BMC Complementary Medicine and Therapies, 2021
Background Integrating systems biology is an approach for investigating metabolic diseases in humans. However, few studies use this approach to investigate the mechanism by which Rhizoma coptidis (RC) reduces the effect of lipids and glucose on high-fat ...
Yanhua Ji, Kexin Luo, Jiri Mutu Zhang, Peng Ni, Wangping Xiong, Xiaoquan Luo, Guoliang Xu, Hongning Liu, Zhijun Zeng   +8 more
doaj   +1 more source

Basic information of TCM health resources.

, 2023
ObjectiveTo analyze the equity of health resource allocation of Traditional Chinese Medicine(TCM) and predict its development during the 14th Five-Year Plan period, and to provide a scientific basis for promoting the improvement of TCM service capacity ...
Minghua Zhou (822341)
core   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Effects of TCMs and Lactobacillus strains on immunosuppressed mice and bacteriostatic effect on Escherichia coli K88 after fermentation

Biotechnology & Biotechnological Equipment, 2019
The aim of this study was to investigate a novel means of treating piglet diarrhoea caused by enterotoxigenic Escherichia coli (ETEC) strain K88 using traditional Chinese medicine (TCM) fermented by selected probiotic strains.
Wei Gu, Mingjie Sun, Wentao Yang, Lirong Wang, Yanlong Jiang, Chunfeng Wang, Guilian Yang   +6 more
doaj   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Concentration index of TCM health resources.

, 2023
ObjectiveTo analyze the equity of health resource allocation of Traditional Chinese Medicine(TCM) and predict its development during the 14th Five-Year Plan period, and to provide a scientific basis for promoting the improvement of TCM service capacity ...
Minghua Zhou (822341)
core   +1 more source

TCM-Mesh: The database and analytical system for network pharmacology analysis for TCM preparations [PDF]

Scientific Reports, 2017
AbstractWith the advancement of systems biology research, we have already seen great progress in pharmacology studies, especially in network pharmacology. Network pharmacology has been proven to be effective for establishing the “compounds-proteins/genes-diseases” network, and revealing the regulation principles of small molecules in a high-throughput ...
Run-zhi Zhang, Shao-jun Yu, Hong Bai, Kang Ning   +3 more
openaire   +3 more sources

Electroacupuncture Improves the Learning and Memory by Modulating Hippocampal Glucose Metabolism through IGF1/IGF1R Signaling in Alzheimer's Disease

Advanced Science, EarlyView.
Electroacupuncture (EA) ameliorates learning and memory function in 5×FAD mice by regulating the brain glucose metabolic network. This neuroprotective effect is closely related to enhancing neuronal energy utilization via the IGF1/IGF1R signaling pathway.
Shengxiang Liang, Qingqing Zhang, Xiuxiu Wang, Lixin Peng, Xinru Ji, Jiawei Wang, Yusi Zhang, Jiayang Huang, Junchao Yang, Shiqi Zhan, Yiping Xiao, Weilin Liu, Lidian Chen   +12 more
wiley   +1 more source

Quercetin alleviates cyclophosphamide-induced premature ovarian insufficiency in mice by reducing mitochondrial oxidative stress and pyroptosis in granulosa cells

Journal of Ovarian Research, 2022
Background Exposure to cyclophosphamide (CTX) induces premature ovarian insufficiency (POI). Quercetin is a natural flavonoid that exhibits anti-inflammatory and antioxidant properties, and its antioxidant activity is correlated with POI.
Yun Chen, Ying Zhao, Chenyun Miao, Liuqing Yang, Ruye Wang, Bixia Chen, Qin Zhang   +6 more
doaj   +1 more source

Development Strategy of Traditional Chinese Medicine in the New Era

中国工程科学, 2023
Traditional Chinese medicine (TCM) develops rapidly in recent years in China; meanwhile, it faces new challenges and shoulders new historical missions.
Xue Xiaojuan , Liu Cai , Wang Yimin , Sun Xiaobo , Cheng Yiyu , Hu Jingqing , Tian Jinzhou , Wang Qi , Zhang Boli   +8 more
doaj   +1 more source