Results 81 to 90 of about 6,776,369 (200)
PROTEOMICS, Volume 25, Issue 15, Page 72-89, August 2025.ABSTRACT Embryo development involves fertilization of a mature ovum, which, after sequential cell divisions (2‐,4‐8‐cells and morula), undergoes differentiation into implantation competent blastocyst. The blastocyst comprises of inner cell mass surrounded by an outer layer of cells called the trophoblast (TSblast) that, upon attachment to the ...
Alin Rai +5 more
wiley +1 more source
The TP53 tumor suppressor gene: From molecular biology to clinical investigations
Journal of Internal Medicine, Volume 298, Issue 2, Page 78-96, August 2025.Abstract Extensively studied over the past four decades, the TP53 gene has emerged as a pivotal watchman in cellular defense and a key factor in cancer biology. TP53 is the most frequently mutated gene in human malignancies, 50% of which carry alterations to it.
Panagiotis Baliakas, Thierry Soussi
wiley +1 more source
ChemBioChem, Volume 26, Issue 10, May 27, 2025.In this concept article, it is discussed how spatial control over the formation and movement of biomolecular condensates (BMCs) can be achieved and how this type of control can help in the reliable generation and study of BMCs. Spatial control over BMCs is crucial in vivo and therefore also desirable for in vitro studies in order to approach relevant ...
Alexander K. Buell
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Abnormal mandibular growth and the condylar cartilage [PDF]
, 2017 Deviations in the growth of the mandibular condyle can affect both the functional occlusion and the aesthetic appearance of the face. The reasons for these growth deviations are numerous and often entail complex sequences of malfunction at the cellular ...
Luder, Hans. U. +3 more
core
Flavour and Fragrance Journal, Volume 40, Issue 3, Page 393-401, May 2025.This article systematically reviews the embryonic development process and gene regulatory mechanisms of the middle ear, with a particular focus on the role of the Tbx1 gene, which is closely associated with middle ear development, in middle ear malformations, especially those involving the ossicular chain.
Xiaochen Gao +7 more
wiley +1 more source
Repercussões Bucais da Síndrome de Treacher Collins: revisão de literatura
Journal Of Oral Investigations, 2018 A Síndrome de Treacher Collins é um distúrbio do desenvolvimento de herança autossômica dominante e expressividade variável que ocorre, devido a um defeito genético com mutações no gene TCOF1, presente no cromossomo 5, que tem 26 éxons e codifica uma ...
Sérgio Spezzia
doaj +1 more source
A ceRNA approach may unveil unexpected contributors to deletion syndromes, the model of 5q- syndrome [PDF]
, 2015 In genomic deletions, gene haploinsufficiency might directly configure a specific disease phenotype. Nevertheless, in some cases no functional association can be identified between haploinsufficient genes and the deletion-associated phenotype ...
Arancio, W. +3 more
core +2 more sources
Treacher Collins syndrome and implications in the oral cavity [PDF]
, 2020 Background and Objective: Treacher Collins syndrome, also called mandibula-facial dysostosis, is a congenital disorder. It is the aim of this work to clarify the etiology, diagnosis, phenotypic craniofacial and oral characteristics of the syndrome, as ...
Cardoso, Inês Lopes, Duque, C.
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Cancer Medicine, Volume 14, Issue 6, March 2025.ABSTRACT Background Hepatocellular carcinoma (HCC) is a major global health issue, with poor prognosis often associated with dysregulated metabolic pathways, especially lactate metabolism. This study explored the prognostic significance of lactate‐associated genes in HCC and their potential as therapeutic targets.
Hao‐ran Qu +12 more
wiley +1 more source