Alcohol exposure induces chick craniofacial bone defects by negatively affecting cranial neural crest development [PDF]
, 2017 Excess alcohol consumption during pregnancy could lead to fetal alcohol syndrome (FAS). However, the molecular mechanism leading to craniofacial abnormality, a feature of FAS, is still poorly understood.
Chuai, Manli +8 more
core +2 more sources
PLoS Genetics, 2012 The cerebral cortex is a specialized region of the brain that processes cognitive, motor, somatosensory, auditory, and visual functions. Its characteristic architecture and size is dependent upon the number of neurons generated during embryogenesis and ...
Daisuke Sakai +3 more
doaj +1 more source
Abnormal mandibular growth and the condylar cartilage [PDF]
, 2017 Deviations in the growth of the mandibular condyle can affect both the functional occlusion and the aesthetic appearance of the face. The reasons for these growth deviations are numerous and often entail complex sequences of malfunction at the cellular ...
Luder, Hans. U. +3 more
core
Investigating DNA-, RNA-, and protein-based features as a means to discriminate pathogenic synonymous variants [PDF]
, 2017 Synonymous single-nucleotide variants (SNVs), although they do not alter the encoded protein sequences, have been implicated in many genetic diseases. Experimental studies indicate that synonymous SNVs can lead to changes in the secondary and tertiary ...
1000 Genomes Project Consortium +85 more
core +3 more sources
PROTEOMICS, Volume 25, Issue 15, Page 72-89, August 2025.ABSTRACT Embryo development involves fertilization of a mature ovum, which, after sequential cell divisions (2‐,4‐8‐cells and morula), undergoes differentiation into implantation competent blastocyst. The blastocyst comprises of inner cell mass surrounded by an outer layer of cells called the trophoblast (TSblast) that, upon attachment to the ...
Alin Rai +5 more
wiley +1 more source
Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine : novel explanation of cardiovascular side effects associated with anti-inflammatory drugs [PDF]
, 2014 © 2014 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.BACKGROUND: Cardiovascular ...
Ahmetaj-Shala, Blerina +13 more
core +4 more sources
The TP53 tumor suppressor gene: From molecular biology to clinical investigations
Journal of Internal Medicine, Volume 298, Issue 2, Page 78-96, August 2025.Abstract Extensively studied over the past four decades, the TP53 gene has emerged as a pivotal watchman in cellular defense and a key factor in cancer biology. TP53 is the most frequently mutated gene in human malignancies, 50% of which carry alterations to it.
Panagiotis Baliakas, Thierry Soussi
wiley +1 more source
ChemBioChem, Volume 26, Issue 10, May 27, 2025.In this concept article, it is discussed how spatial control over the formation and movement of biomolecular condensates (BMCs) can be achieved and how this type of control can help in the reliable generation and study of BMCs. Spatial control over BMCs is crucial in vivo and therefore also desirable for in vitro studies in order to approach relevant ...
Alexander K. Buell
wiley +1 more source
Integration of protein phosphorylation, acetylation, and methylation data sets to outline lung cancer signaling networks [PDF]
, 2018 Integrated multiomics network analysis reveals signaling profiles in lung cancer.
Clark, Neil R. +14 more
core +1 more source
Phenotype Similarity Regression for Identifying the Genetic Determinants of Rare Diseases. [PDF]
, 2016 Rare genetic disorders, which can now be studied systematically with affordable genome sequencing, are often caused by high-penetrance rare variants.
Greene, Daniel +3 more
core +3 more sources