Results 231 to 240 of about 8,833 (297)

Tropical Cyclone Rainfall Spatial Asymmetries in the Lesser Antilles

open access: yesInternational Journal of Climatology, Volume 46, Issue 8, 30 June 2026.
Rainfall is not proportional to the Saffir‐Simpson wind‐based categories. Lower category tropical cyclones (TS, H1, H2 and H3) can generate more intense rainfall than H4 and H5. Rainfall is asymmetric; as a tropical cyclone intensifies or weakens, the location of peak rainfall shifts.
Catherine Nabukulu   +3 more
wiley   +1 more source

Click Capture SELEX for the Identification of Click‐Modified Aptamers Targeting Small Molecules in Solution

open access: yesChemistry – A European Journal, Volume 32, Issue 23, 16 June 2026.
Using kanamycin A as a model target, we developed click‐capture SELEX to identify nucleobase‐modified aptamers capable of binding small molecules in solution. This approach enables flexible incorporation of nucleobase modifications via CuAAC, allowing the chemical properties of the aptamer to be tailored to the target molecule.
Philipp Menke   +5 more
wiley   +1 more source

Probing 3‐Amino‐2H‐Azaindazoles as Allosteric Inhibitors of the Protein Tyrosine Phosphatase SHP2

open access: yesChemMedChem, Volume 21, Issue 11, 15 June 2026.
A palladium‐catalyzed domino reaction facilitated the discovery and rapid synthesis of selective, potent 3‐amino‐2H‐azaindazole derivatives serving as allosteric inhibitors of SHP2. Structural analysis via co‐crystallography confirmed binding at the allosteric site, thereby stabilizing the autoinhibited SHP2 conformation, qualifying this scaffold as a ...
Machoud Amoussa   +20 more
wiley   +1 more source

Home - About - Disclaimer - Privacy