Results 101 to 110 of about 438,341 (309)

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

Dual Pathways From Self-Compassion and Self-Criticism to Academic Achievement: The Roles of Engagement and Exhaustion

Perspectives on Medical Education
Background: Engagement and burnout symptoms among medical students are key factors influencing their academic performance, risk of dropout, and overall well-being. While research has primarily focused on negative constructs such as burnout symptoms, less
Piermarco Consiglio, Marjon Fokkens-Bruinsma, Marie-Christine Opdenakker, Ellen P. W. A. Jansen, Joke Fleer   +4 more
doaj   +1 more source

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source

A Case for Student Teacher Placement as Preparation for Future Urban Educators

, 2011
Do schools of education effectively train young, white, and middle-class teacher candidates to work in urban classrooms? How can schools of education prepare teachers and future teachers for classrooms that are diverse in terms of race/ethnicity ...
Espinor, Debra S.
core  

Cohort‐Scale Spatial Autocorrelation for Tumor Prediction in Mid‐Infrared Pathology and Spatial Biomarker Discovery Using MALDI Imaging Lipidomics

Advanced Science, EarlyView.
Computational annotation of various tissue types in heterogeneous samples such as colorectal cancer liver metastasis (CRLM) using spatial autocorrelation analysis on non‐destructive mid‐infrared (MIR) imaging data enabled correlative multimodal mass spectrometry imaging (MSI) for spatial investigation of lipid tumor marker candidates. The method can be
Miriam F. Rittel, Nikolas Ebert, Denis Abu Sammour, Sebastian Graf, Björn C. Fröhlich, Emrullah Birgin, Shad A. Mohammed, Nuh N. Rahbari, Axel Wellmann, Oliver Wasenmüller, Cleo‐Aron Weis, Stefan Schmidt, Carsten Hopf   +12 more
wiley   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

The overseas trained teacher programme in England 2006/07 : information to providers [PDF]

, 2006
This booklet is for schools interested in using the overseas trained teacher programme (OTTP) to train a teacher. It provides an overview of the programme and guidance on: • applying for the OTTP • the organisations involved • trainee entry ...

core  

Preparing Teacher Candidates to Serve Students From Diverse Backgrounds: Triggering Transformative Learning Through Short-Term Cultural Immersion

, 2014
This study followed 24 teacher candidates in a short-term cultural immersion field experience designed to help them reflect on their assumptions and perspectives in order to better understand the culturally, ethnically, and linguistically diverse ...
Addleman, Rebecca A., Brazo, Carol J., Cevallos, Tatiana, Dixon, Kriston, Nava, Robert Ch.   +4 more
core   +1 more source

Targeting PRKCN, an Essential Driver Orchestrating mTOR‐IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma

Advanced Science, EarlyView.
Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang, Dongpeng Jiang, Peng Ke, Xiaosen Bian, Lili Zhang, Ying Zhang, Tingting Zhu, Weiwei Qu, Wenhui Qi, Yang Xu, Chengcheng Fu, Depei Wu, Jianhong Chu   +12 more
wiley   +1 more source

運用設計思考促進國小學生 探究實作之行動研究 Action Research on Utilizing Design Thinking to Facilitate Elementary School Students’ Inquiry and Practical Learning

Journal of Curriculum Studies
本研究旨在運用設計思考引導國小學生進行校園環境改造之探究實作，以促進學生在學習歷程的主動性。本研究採行動研究，為期一學年，以苗栗市兩個高年級班級共55位學生為參與對象。藉由參與觀察、文件分析及晤談方法蒐集資料。研究發現：一、課程發展歷程：在第一次發散與收斂階段，從生活真實情境出發，能深化學生問題解決的投入意願和理解他人需求的同理心；第二次發散與收斂階段，透過賦予團體行動任務，能促進學生創造力和實踐行動力；二、教學實踐歷程：探究弧與設計思考步驟可搭配對應，透過思考與行動兩者的連結 ...
洪麗卿 Li-Ching Hung, 羅靖姈 Ching-Ling Lo   +1 more
doaj   +1 more source