Results 101 to 110 of about 12,663 (268)

運用設計思考促進國小學生 探究實作之行動研究 Action Research on Utilizing Design Thinking to Facilitate Elementary School Students’ Inquiry and Practical Learning

Journal of Curriculum Studies
本研究旨在運用設計思考引導國小學生進行校園環境改造之探究實作，以促進學生在學習歷程的主動性。本研究採行動研究，為期一學年，以苗栗市兩個高年級班級共55位學生為參與對象。藉由參與觀察、文件分析及晤談方法蒐集資料。研究發現：一、課程發展歷程：在第一次發散與收斂階段，從生活真實情境出發，能深化學生問題解決的投入意願和理解他人需求的同理心；第二次發散與收斂階段，透過賦予團體行動任務，能促進學生創造力和實踐行動力；二、教學實踐歷程：探究弧與設計思考步驟可搭配對應，透過思考與行動兩者的連結 ...
洪麗卿 Li-Ching Hung, 羅靖姈 Ching-Ling Lo   +1 more
doaj   +1 more source

A Bone Marrow–Mimetic Hydrogel Enables Dual‐Phase Hemostasis and Vascularized Osteogenesis for Cranial Defects

Advanced Science, EarlyView.
A biomimetic, fiber‐reinforced hydrogel (FE‐PDA@Fib/Gel‐TG) that enables dual‐phase cranial defect repair. The system provides: instant hemostasis in the early stage, and sustained co‐delivery of pro‐angiogenic and osteogenic signals for synergistic vascularized bone regeneration.
Lingbin Che, Donghong Li, Huan Zhang, Tingting Xu, Juhan Li, Xuanzhou Chen, Louis D. Zhang, Shuguang Wang, Dianwen Song, Dongyong Sha   +9 more
wiley   +1 more source

Disaster Preparedness: Beliefs of Physical Education Teacher Education Majors

Sakarya University Journal of Education
This study examined the differences in disaster preparedness beliefs among physical education teacher candidates based on gender and grade level. A total of one hundred and forty-nine physical education teacher candidates, 61 male and 88 female took part
Zeynep Dinç, Leyla Saraç
doaj   +1 more source

Tumor‐Infiltrating mregDCs Restrain Anti‐Tumor Immunity in Early Relapse HCC

Advanced Science, EarlyView.
Tumor‐infiltrating mregDCs are regulated by the TNFR2‐non‐canonical NF‐κB axis, which is mediated by TNF‐α secreted by CD161+CD8+ T cells. These mregDCs recruit CD161+CD8+ T cells via the CCL20‐CCR6 axis, forming a positive feedback loop that enhances immunosuppression, promotes early recurrence of HCC, and further confirms TNFR2 as a key therapeutic ...
Zefan Zhang, Lin Ding, Yu Zhong, Haokang Feng, Linglong Huang, Waidong Huang, Chunqing Wang, Arne Östman, Beili Wang, Jian Zhou, Jia Fan, Wei Guo, Liang Wu, Yunfan Sun   +13 more
wiley   +1 more source

Inhibitory Decay and Supercritical Brain Dynamics During Sleep Deprivation

Advanced Science, EarlyView.
Sleep deprivation progressively shifts human brain dynamics from near‐critical toward supercritical states, as revealed by neuronal avalanche analysis of resting‐state fMRI. These changes track subjective sleep pressure rather than vigilance lapses and show marked network heterogeneity. A circuit model suggests that reduced inhibitory efficacy provides
Dai Zhang, Liqin Zhou, Rong Wang, Yuehua Han, Zhentao Zuo, Yanghua Tian, Ke Zhou   +6 more
wiley   +1 more source

A Study on the Environmental Attitudes of Candidate Teachers

, 2014
Bu araştırma, Niğde Üniversitesi Eğitim Fakültesi Sınıf Öğretmenliği, Fen Bilgisi Öğretmenliği ve Sosyal Bilgiler Öğretmenliği lisans programlarında öğrenim gören dördüncü sınıf öğretmen adaylarının çevreye karşı tutumlarını belirlemeyi amaçlamaktadır.
YALÇINKAYA, Elvan, KARATAŞ, Abdullah, TALAS, Mustafa   +2 more
openaire   +3 more sources

NLSS3 Impairs SHM1 Autophagic Degradation to Regulate Leaf Morphology and Salt Tolerance in Rice

Advanced Science, EarlyView.
In rice, NLSS3 binds and shields SHM1 from autophagic degradation to maintain serine homeostasis. The A132P mutation in nlss3 disrupts this, triggering SHM1 loss, metabolic dysfunction, K+ imbalance, and impaired ROS scavenging, which collectively drive narrow leaves and salt sensitivity.
Xiong Liu, Yulu Yang, Zhiqi Hao, Jing Xu, Huibo Zhao, Qiang Zhang, Deyong Ren, Xia Li, Guojun Dong, Lan Shen, Li Zhu, Jiang Hu, Zhenyu Gao, Qing Li, Qian Qian, Guangheng Zhang   +15 more
wiley   +1 more source

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

How Advanced Artificial Intelligence Technologies Shape Drug–Drug and Drug–Target Interaction Modeling

Advanced Science, EarlyView.
This review explores the convergence of artificial intelligence technologies in modeling drug–drug and drug–target interactions. By evaluating advanced feature engineering, architectural innovations, and learning paradigms reveals shared evolutionary trends and critical challenges, such as cold‐start settings and shortcut learning.
Xin Sun, Tong Wang
wiley   +1 more source