Results 71 to 80 of about 439,667 (314)

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

Developing the Islamic culture curriculum according to the purposes of Sharia to enhance some of the values of intellectual security among Al-Azhar secondary school students [PDF]

International Journal of Instructional Technology and Educational Studies
curriculum developed in Islamicculture in the light of the Sharia objectives in promoting the values of the intellectual security for Al-Azhar 1st grade secondary stage .
Walaa Al- Hawwary
doaj   +1 more source

AutomataGPT: Transformer‐Based Forecasting and Ruleset Inference for Two‐Dimensional Cellular Automata

Advanced Science, EarlyView.
We introduce AutomataGPT, a generative pretrained transformer (GPT) trained on synthetic spatiotemporal data from 2D cellular automata to learn symbolic rules. Demonstrating strong performance on both forward and inverse tasks, AutomataGPT establishes a scalable, domain‐agnostic framework for interpretable modeling, paving the way for future ...
Jaime A. Berkovich, Noah S. David, Markus J. Buehler   +2 more
wiley   +1 more source

The use of complaints in the inter-language of Turkish EFL learners (El uso de los reclamos en el Inter-lenguaje de estudiantes de Inglés como lengua extranjera en Turquía) [PDF]

, 2010
Many Turkish EFL learners struggle with giving complaints and criticisms in the EFL classroom. Language instructors must find way to provide students with the linguistic and pragmatic elements of EFL to be able to appropriately complain as EFL users. The
Deveci, Tanju
core  

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

Piloting a Digitized Evidence-Based Assessment System

, 2006
One of the most difficult challenges facing university-based teacher education programs is to document program effectiveness. Demands for supporting data come from a number of different constituencies including state legislators, hiring officials and ...
Pool, Jonelle, Stebick, Divonna M.
core   +1 more source

Picturing Teacher Agency: Developing Upstanding Heuristics in a Middle Grades Social Studies Methods Course [PDF]

, 2019
This paper presents a multi-case study of teacher candidates in a pre-service middle grades social studies methods course. The research aimed to understand how the middle grades teacher candidates viewed their future as upstanders with agency in middle ...
Farley, Jennifer, Gallagher, Jennifer L
core   +2 more sources

Learning to Prove Safety over Parameterised Concurrent Systems (Full Version)

, 2017
We revisit the classic problem of proving safety over parameterised concurrent systems, i.e., an infinite family of finite-state concurrent systems that are represented by some finite (symbolic) means.
bertrand, boigelot, boigelot, bollig, donaldson, esparza, fokkink, kearns, legay, lehmann, lin, neider, nilsson, vardhan   +13 more
core   +2 more sources

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Fostering teacher candidate dispositions in teacher education programs

Journal of the Scholarship of Teaching and Learning, 2013
The role of teacher preparation programs is to ensure that candidates are effectively prepared in the knowledge, skills and dispositions needed to be an effective educator.
Lauren L. Cummins, Bridget Asempapa
doaj