Results 131 to 140 of about 3,794,363 (398)

The Nuclear Receptor NR1B1/RARα Arrests the Differentiation of Anti‐Tumor Effector Cytotoxic T Cells

open access: yesAdvanced Science, EarlyView.
RARα is highly expressed by differentiated effector and exhausted T cells and exerts a negative effect on effector T cell differentiation and the associated trafficking receptor switch. Upregulated RARα levels decrease the nuclear histone acetylase (HAT) activity, and this suppresses the expression of key Teff transcription factor BATF and trafficking ...
Patrick Niekamp   +5 more
wiley   +1 more source

Optimization of Ultrasonic-assisted Extraction of Fatty Acids in Seeds of Brucea Javanica (L.) Merr. from Different Sources and Simultaneous Analysis Using High-Performance Liquid Chromatography with Charged Aerosol Detection

open access: yesMolecules, 2017
Our research aimed to optimize the oil extraction process and determine the fatty acids in Brucea javanica (L.) Merr. seeds. The extraction technology was optimized using response surface methodology.
Zhuona Wu   +7 more
doaj   +1 more source

The Teaching and Learning of Psychotherapy.

open access: yes, 1959
Modern psychiatry is at present involved in perfecting and discriminating various psychotherapeutic techniques. There are many studies now supported with adequate funds that are oriented toward understanding the therapeutic relationships that offer ...
R. Grinker
semanticscholar   +1 more source

Dipping Into the Weekly Reader Mailbag: You Have Questions? We Have Answers! [PDF]

open access: yes, 2014
https://digitalcommons.winthrop.edu/weeklyreader/1042/thumbnail ...
Bird, John, Teaching and Learning Center
core   +1 more source

State of the Art of Low‐Frequency Acoustic Modulation: Intensity Enhancement and Directional Control

open access: yesAdvanced Science, EarlyView.
High intensity low‐frequency sound sources hold significant value in many fields. However, their long wavelength, strong penetrability, and tendency to diffract make direction control and intensity enhancement challenging. Acoustic generators and metamaterial‐based acoustic devices still face issues such as low energy efficiency, poor directional ...
Jingsong Xu   +13 more
wiley   +1 more source

Beyond Participatory Design: Towards a Model for Teaching Seniors Application Design [PDF]

open access: yesarXiv, 2017
Population aging and the ubiquity of technology in everyday life have made designing solutions for older adults a necessity. User-centered and participatory design approaches include elderly users in the software development process to some extent but do not encourage them to take a leading role in designing applications to address their unmet needs ...
arxiv  

Warnings From the Trenches - But I Thought We Were in the Trenches! [PDF]

open access: yes, 2013
https://digitalcommons.winthrop.edu/weeklyreader/1019/thumbnail ...
Bird, John, Teaching and Learning Center
core   +1 more source

PLXDC1+ Tumor‐Associated Pancreatic Stellate Cells Promote Desmoplastic and Immunosuppressive Niche in Pancreatic Ductal Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
This study uncovers the activation, heterogeneity, and regulatory roles of pancreatic stellate cells (PSCs) at single‐cell and spatial levels. It further identifies PLXDC1+ PSCs near aggressive LRRC15+ cancer‐associated myofibroblasts and SPP1+ macrophages, forming a desmoplastic and immunosuppressive tumor niche that promotes CD8+ T cell exhaustion ...
Yanhua Du   +12 more
wiley   +1 more source

Guest Column: College Students and Stress: What Can We Do to Help? [PDF]

open access: yes, 2016
https://digitalcommons.winthrop.edu/weeklyreader/1094/thumbnail ...
Hamill, Shelley   +1 more
core   +1 more source

A Rapid Cortical Learning Process Supporting Students’ Knowledge Construction During Real Classroom Teaching

open access: yesAdvanced Science, EarlyView.
There is growing interest in understanding how classroom teaching works, but previous theories and studies leave a gap in the neurocognitive mechanisms involved in real classroom teaching. Here we show that during real classroom teaching, students' middle frontal cortex serves as a hub of a rapid cortical learning process, supporting their knowledge ...
Xiaodan Feng   +6 more
wiley   +1 more source

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