Results 201 to 210 of about 1,205,812 (344)

Assessing the Nature of Human Brain‐Derived Extracellular Vesicles on Synaptic Activity Via the Development of an Air‐liquid Microfluidic Platform

open access: yesAdvanced Science, EarlyView.
This seminal study highlights the interwoven and tightly regulated functions of brain‐derived extracellular vesicles. Using microfluidics, proteomics, and AI‐based electric signal analyses of cortical brain explants, this work provides a useful resource dataset revealing the composition of human brain‐derived extracellular vesicles obtained from ...
Corentin Bernou   +14 more
wiley   +1 more source

Shannon Entropy of Gray Matter Eigenmodes: A Novel Biomarker for Alzheimer's Disease and Heterogeneous MCI Trajectories

open access: yesAdvanced Science, EarlyView.
Entropy derived from gray matter eigenmodes captures cortical disorganization in Alzheimer's disease. Using multimodal MRI and amyloid‐PET data, this novel structure–function coupling biomarker enables accurate classification of clinical stages, predicts Aβ burden, and stratifies mild cognitive impairment subtypes.
Yumeng Li   +5 more
wiley   +1 more source

Student ndash; centered learning and teaching

open access: yes
Dezvoltarea personală este un proces fundamental în viața oricărui individ. Pornind de la acest deziderat, acest studiu încearcă să determine eficacitatea acestei abordări. Instruirea centrată pe elev reprezintă o metodologie de ghidare care se concentrează pe implicarea activă a elevului în procesul de învățare.
openaire   +1 more source

Accurate Generation of Conformational Ensembles for Intrinsically Disordered Proteins with IDPFold

open access: yesAdvanced Science, EarlyView.
In brief: IDPFold predicts the conformational ensembles of intrinsically disordered proteins (IDPs) from their amino acid sequences. The atomic structures generated by IDPFold offer crucial insights into the intricate relationship between IDP structures and their diverse biological functions.2 Abstract Intrinsically disordered proteins (IDPs) play ...
Junjie Zhu   +10 more
wiley   +1 more source

Rapid Arbitrary‐Shape Microscopy of Unsectioned Tissues for Precise Intraoperative Tumor Margin Assessment

open access: yesAdvanced Science, EarlyView.
This study presents a novel microscopic imaging system capable of rapid, section‐free scanning of irregular tissue surfaces, delivering high sensitivity for detecting cancer cell clusters during intraoperative tumor margin assessment. Abstract Rapid and accurate intraoperative examination of tumor margins is crucial for precise surgical treatment, yet ...
Zhicheng Shao   +17 more
wiley   +1 more source

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