Results 141 to 150 of about 7,301,955 (359)

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

open access: yesAdvanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu   +20 more
wiley   +1 more source

Calcium Channel Blockers Inhibit Pancreatic Neuroendocrine Neoplasms Progression via Cav1.2‐Epigenetic Circuit

open access: yesAdvanced Science, EarlyView.
Our study reveals a novel mechanism of a positive regulatory circuit between Cav1.2 and H3K27ac for pancreatic neuroendocrine neoplasms (pNENs) progression. Cav1.2 is identified as a crucial target for promoting disease progression and correlates with malignant behaviors, which are remarkably inhibited by the administration of calcium channel blockers (
Yangyinhui Yu   +12 more
wiley   +1 more source

Intention to practice telemedicine by health workers in a teaching hospital in Northcentral Nigeria, 2022

open access: yesJournal of Interventional Epidemiology and Public Health
Introduction: The practice of telemedicine is generally poor in low and middle-income countries, including Nigeria, which has utilization rates below 5%, in contrast to nearly 80% reported in high-income countries.
Eric Yila   +2 more
doaj   +1 more source

Hospital and home teachers' views about teaching students who have medically defined mental health needs [PDF]

open access: yes, 2007
Rising numbers of students with medically defined mental health needs are being referred to some hospital and home teaching services (HHTS). In July 2006 hospital and home teachers were surveyed about how this affects their work, in order to share ...
Alderson, Priscilla, Perera, Mala
core   +1 more source

Cardiac manifestations of acute carbamate and organophosphate poisoning.

open access: yesHeart, 1997
A. Saadeh   +10 more
semanticscholar   +1 more source

Cohort‐Scale Spatial Autocorrelation for Tumor Prediction in Mid‐Infrared Pathology and Spatial Biomarker Discovery Using MALDI Imaging Lipidomics

open access: yesAdvanced Science, EarlyView.
Computational annotation of various tissue types in heterogeneous samples such as colorectal cancer liver metastasis (CRLM) using spatial autocorrelation analysis on non‐destructive mid‐infrared (MIR) imaging data enabled correlative multimodal mass spectrometry imaging (MSI) for spatial investigation of lipid tumor marker candidates. The method can be
Miriam F. Rittel   +12 more
wiley   +1 more source

Job Satisfaction of Nurses from Clinical Practice in Jiroft University Hospitals

open access: yesنشریه پرستاری ایران, 2015
Background & Aim: Job satisfaction is the level of employees' feelings regarding their jobs in most the health care organizations nurses are the largest human resources and play a major role in the quality of services, thus their satisfaction and ...
M Faramarzpour, F Borhani, P Bagheri
doaj  

Nurses' barriers to the pressure ulcer risk assessment scales implementation: A phenomenological study

open access: yesNursing Open
Aim The aim of the study was to explore nurses' barriers to the pressure ulcer risk assessment scales implementation. Design A qualitative descriptive phenomenological study. Methods The research participants comprised of 10 nurses at various medical and
Nestor Tomas, Annalisa M. Mandume
doaj   +1 more source

A Survey of Knowledge and Attitudes of Directors in Educational Hospitals of Tabriz University of Medical Sciences about Sterategic Planning [PDF]

open access: yesTaṣvīr-i salāmat, 2016
Background and objectives : This study aimed to assess the knowledge and attitudes of managers of hospitals in Tabriz University of Medical Sciences in the field of strategic planning that was done in 2013.
Massumeh gholizadeh   +5 more
doaj  

Readiness for Discharge in Parents of Hospitalized Children [PDF]

open access: yes, 2008
Parental preparation for a child\u27s discharge from the hospital sets the stage for successful transitioning to care and recovery at home. In this study of 135 parents of hospitalized children, the quality of discharge teaching, particularly the nurses ...
Jerofke, Teresa A.   +5 more
core   +1 more source

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