Results 101 to 110 of about 602,470 (307)

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Regional Variation in Attitude of Mental Health Professionals Towards Tackling Illicit Drug-use and Drug-related Disorders [PDF]

, 2017
This study sought to assess the attitudes of Mental Health Professionals (MHPs) towards tackling illicit drug use and drug-related disorders in Nigeria and to explore regional variations in attitude. Based on the validated Substance Abuse Attitude Survey
Akinola, O. (Olubusayo), Kuo, W. (Wen-Hung), Obisesan, O. (Olawunmi), Oswald, J. (John)   +3 more
core  

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

Advanced Science, EarlyView.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S. M. Shatil Shahriar, Jingwei Xie   +4 more
wiley   +1 more source

Creating the Health Care Team of the Future: The Toronto Model for Interprofessional Education and Practice [PDF]

, 2014
[Excerpt] In 2000, the Institute of Medicine\u27s landmark report To Err Is Human launched the contemporary patient safety movement with its clarion call to the health care systems all over the globe to act to prevent the errors that kill over 100,000 ...
Hodges, Brian D, Nelson, Sioban, Tassone, Maria   +2 more
core   +1 more source

AI‐Assisted Self‐Powered Wearable Dual‐Mode Sensor With TENG and Stretchable Optical Fiber for Neurological Disorder Diagnostics

Advanced Science, EarlyView.
This manuscript presents the WDMS platform, an AI‐assisted, self‐powered wearable dual‐mode sensor for tele‐neurology. It integrates a contact–separation TENG insole with stretchable polyurethane optical‐fiber strain sensors to synchronously track plantar pressure and lower‐limb muscle deformation.
Tianliang Li, Han Liu, Guoxu Liu, Qian'ao Wang, Haotian Zhou, Guiyi Liu, Yan Xu, Jun Wang, Zuqiang Wang, Feng Zhu, Feiling Luo, Zhong Lin Wang, Chi Zhang   +12 more
wiley   +1 more source

Prevalence and clinical correlates of liver function test abnormalities in acute heart failure

The Egyptian Journal of Internal Medicine
Background In Africa, heart failure is an important cause of death. In acute heart failure (AHF) liver function test (LFT) abnormalities have been shown to be widespread in the industrialized nations and to be somewhat linked to adverse outcomes. However,
Olumide Akinniyi Akinyele, Rasaaq Ayodele Adebayo, Michael Olabode Balogun, Dennis Amajuoyi Ndububa, Anthony Olubunmi Akintomide, Oladipo Ayoola Olanipekun, Obafemi Sunday Adesanya, Busayo Onafowoke Oguntola   +7 more
doaj   +1 more source

Soft Robotics and Advanced Technologies for Minimally Invasive Bioprinting: The Future of Internal Organ Repair

Advanced Science, EarlyView.
This review examines the evolution of bioprinting toward minimally invasive in situ strategies for internal organ regeneration. It defines the technological roadmap from handheld systems to advanced minimally invasive bioprinting platforms, positioning soft robotics as a core enabler.
Duc Tu Vu, Nhu An Phan, Sy Trung Ngo, Minh Tri Phan, Thanh‐An Truong, Chi Cong Nguyen, Phuoc Thien Phan, Hoang‐Phuong Phan, Thanh Nho Do, Mai Thanh Thai   +9 more
wiley   +1 more source

A Pre-Katrina Look At the Health Care Delivery System for Low-Income People in New Orleans [PDF]

, 2006
Provides an overview of the public safety net structure, and how health care was delivered to the low-income and uninsured residents of New Orleans before Hurricane Katrina.

core  

Bioinspired Engineering of Streamlined Skeletal Interoception: Neural Bioprinted Piezoelectric Scaffolds for Neuro‐Vascularized Bone Regeneration

Advanced Science, EarlyView.
This study develops neural bioprinted piezoelectric scaffolds which construct local “sensor‐effector” circuit, inspired by the skeletal interoception system. Upon US stimulation sensing and mechanoelectrical coupling by PLLA nanofibers, the incorporated DRG neurons effect through Ca2+ influx‐induced enhanced secretion and expression of CGRP.
Yingze Su, Haomin Wang, Weixi Liu, Kangming Chen, Yiyang Min, Jinbo Zhu, Xueyang Li, Anning Su, Hao Yang, Lei Yang, Yun Ji, Yuxin Zhang, Jisi Zheng, Chi Yang, Chuanglong He, Tao Li, Shuo Chen, Tao Wu, Xiaodong Chen   +18 more
wiley   +1 more source

Laparoscopic Colorectal Surgery in the Era of Robotics: Evolution, Eclipse, or Equilibrium?

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Minimally invasive colorectal surgery has undergone a remarkable transformation over the past three decades. Laparoscopy, once viewed with skepticism, is now firmly established as a standard approach, supported by robust randomized trials demonstrating oncologic safety and improved recovery compared to open surgery.
Amanjeet Singh, Archit Gupta, Azhar Perwaiz, Adarsh Chaudhary   +3 more
wiley   +1 more source