NIBAN2/FLII/RREB1 Axis Drives Glioma Stem Cell Malignancy via TLR3 Pathway Activation
NIBAN2, highly expressed in glioma stem‐like cells (GSCs), assembles with FLII and transcription factor RREB1 to form a nuclear complex. This complex transcriptionally activates stemness‐associated genes (e.g., CD44, NANOG) and metabolic enzymes (e.g., LDHA), thereby sustaining both transcriptional and metabolic stemness programs.
Liang liang Shi +14 more
wiley +1 more source
Many Hands Make Stronger Work: Building Cross-Institutional Undergraduate Research Experiences Using Universal Design for Learning. [PDF]
Podowitz-Thomas S +6 more
europepmc +1 more source
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska +14 more
wiley +1 more source
Building an interactive dashboard to visualize institutional open access publishing trends. [PDF]
Gorman EF, Shelawala N, Yarnell A.
europepmc +1 more source
O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu +10 more
wiley +1 more source
Building implementation science capacity: Adaptation of I-Corps™@NCATS training for rapid fit-to-context discovery and designing for scale-up and sustainability. [PDF]
Morrato EH +4 more
europepmc +1 more source
Transcreating approaches to addressing disproportionate impacts on health in Colorado communities: the Colorado Community Engagement Alliance multi-year study. [PDF]
Warman MK +10 more
europepmc +1 more source
Striking a Balance With Business and Engineering Content in Biomedical Engineering Capstone Design. [PDF]
Eberhardt AW.
europepmc +1 more source

