Results 271 to 280 of about 2,422,399 (342)

NIBAN2/FLII/RREB1 Axis Drives Glioma Stem Cell Malignancy via TLR3 Pathway Activation

open access: yesAdvanced Science, EarlyView.
NIBAN2, highly expressed in glioma stem‐like cells (GSCs), assembles with FLII and transcription factor RREB1 to form a nuclear complex. This complex transcriptionally activates stemness‐associated genes (e.g., CD44, NANOG) and metabolic enzymes (e.g., LDHA), thereby sustaining both transcriptional and metabolic stemness programs.
Liang liang Shi   +14 more
wiley   +1 more source

Building Capacity in Institutional Operational Research in Low-Resource Settings: Protocol for an Implementation Research Study.

open access: yesJMIR Res Protoc
Ali S   +16 more
europepmc   +1 more source

Many Hands Make Stronger Work: Building Cross-Institutional Undergraduate Research Experiences Using Universal Design for Learning. [PDF]

open access: yesACS Omega
Podowitz-Thomas S   +6 more
europepmc   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

open access: yesAdvanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska   +14 more
wiley   +1 more source

O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

open access: yesAdvanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu   +10 more
wiley   +1 more source

Transcreating approaches to addressing disproportionate impacts on health in Colorado communities: the Colorado Community Engagement Alliance multi-year study. [PDF]

open access: yesFront Public Health
Warman MK   +10 more
europepmc   +1 more source

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