Results 271 to 280 of about 2,615,759 (367)

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

MiMeDB 2.0: the Human Microbial Metabolome Database for 2026. [PDF]

Nucleic Acids Res
Kruger R, Oler E, Saha S, Poelzer J, Han S, Punsalan MP, Green B, Bushra F, Kyes M, Disu F, Wakoli J, Woudstra R, Tejol E, Fakutan O, Wang F, Lee BL, Sajed T, Tian S, Torres-Calzada C, Berjanskii M, MacKay S, Karu N, Kadurrah-Daouk R, Wishart DS.   +23 more
europepmc   +1 more source

The Effect of a Teams Knowledge Management Practices on Team Performance : Evidence from Sri Lankan Software Development Companies and Business Process Outsourcing Companies

, 2018
J.A.S.K. Jayakody, W.B.M.D. Basnayake
openalex   +1 more source

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

Sex and gender influences on problematic cannabis use and cannabis use disorder: A scoping review protocol. [PDF]

PLoS One
Matheson J, Mielnik CA, Knight R, Wright M, Marley N, Bonato S, Le Foll B, Gallagher L, Rubin-Kahana DS.   +8 more
europepmc   +1 more source

A Time‐Programmed Bilayer Wound Dressing for Dynamic Microenvironment Modulation and Full‐Thickness Regeneration in Diabetic Wounds

Advanced Science, EarlyView.
The Polyphenol+PDGF‐BB scaffold fabrication (Panel A) and its dual wound healing effects (Panel B: anti‐inflammation and accelerated tissue remodeling). ABSTRACT Chronic diabetic wounds suffer from dysfunctional repair programs due to accumulated advanced glycation end products (AGEs) and persistent inflammation in hyperglycemic microenvironments ...
Lei Yi, Wanqian Li, Ying Duanmu, Zihan Zhang, Shixuan Chen, Shichu Xiao, Lei Du, Miaomiao Wei   +7 more
wiley   +1 more source

Implementation of Virtual Focus Groups as an Effective Strategy in Qualitative Research to Engage With Undersupported Communities: Protocol for Virtual Focus Groups.

JMIR Res Protoc
Ramos-Lucca A, Motta-Pagán JL, Vélez-Mojica K, Matos-Castro J, Rodríguez-Torruella D, Vélez-Maldonado DA, Rosario-Maldonado FJ, Aguirre-Hernández J, Morales-Torres L, Castro-Figueroa E, Rivera-Mateo E, Marzán-Rodríguez M, Jiménez-Chávez J.   +12 more
europepmc   +1 more source

UpSMART: five years of digital innovation in cancer clinical research-achievements, challenges, and recommendations. [PDF]

Front Digit Health
O'Regan P, Butt F, Carter L, Graham DM, Le Blanc A, Hoskins R, Stephenson L, Patil A, Shabbir M, Eken D, Singh S, Villa A, Agnelli L, Damian S, Grave C, Pretelli G, Garralda E, Frost H, de Braud F, Freitas A, Dive C, Unsworth H.   +21 more
europepmc   +1 more source

Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

Advanced Science, EarlyView.
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli, Daniel Levy, Alyssa Schledwitz, Natalia Sampaio Moura, Mitali Sarkar, Talia J. Solomon, Emily H. Powsner, Raith Nowak, Zuzanna Mamczarz, Christopher J. Bridgeman, Sulayman Khan, Andrew Hui, Nidhi Anne, Laura Reus, William E. Bentley, Jean‐Pierre Raufman, Steven M. Jay   +16 more
wiley   +1 more source

A framework for reconfigurable production line changeover task planning based on large language model. [PDF]

Sci Rep
Hou J, Yan L, Qiang H.
europepmc   +1 more source