Results 91 to 100 of about 442,895 (373)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Fast Magnetic Reconnection: "Ideal" Tearing and the Hall Effect

, 2017
One of the main questions in magnetic reconnection is the origin of triggering behavior with on/off properties that accounts, once it is activated, for the fast magnetic energy conversion to kinetic and thermal energies at the heart of explosive events ...
Pucci, Fulvia, Tenerani, Anna, Velli, Marco   +2 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Dissipation in Poynting-flux Dominated Flows: the Sigma-Problem of the Crab Pulsar Wind

, 2003
Flows in which energy is transported predominantly as Poynting flux are thought to occur in pulsars, gamma-ray bursts and relativistic jets from compact objects.
Bogovalov S. V., Buckley R., Harris E. G., J. G. Kirk, Lyubarsky Y., Melatos A., O. Skjaraasen, Rees M. J., Schopper R., Spruit H. C., Thompson C., Usov V. V., Zelenyi L. M.   +12 more
core   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Effects of Tearing on the Perception of Facial Expressions of Emotion

Evolutionary Psychology, 2015
What is the function of emotional tearing? Previous work has found a tear effect, which resolves ambiguity in neutral expressions and increases perceptions of sadness in sad expressions. Tearing, however, is associated with a variety of emotional states,
Lawrence Ian Reed, Paul Deutchman, Karen L. Schmidt   +2 more
doaj   +1 more source

Finite-distance singularities in the tearing of thin sheets

, 2011
We investigate the interaction between two cracks propagating in a thin sheet. Two different experimental geometries allow us to tear sheets by imposing an out-of-plane shear loading.
A. Boudaoud, E. Bayart, G. I. Barenblatt, J. B. Leblond, L. B. Freund, M. Adda-Bedia   +5 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

3D reconnection due to oblique modes: a simulation of Harris current sheets [PDF]

Nonlinear Processes in Geophysics, 2000
Simulations in three dimensions of a Harris current sheet with mass ratio, mi/me = 180, and current sheet thickness, pi/L = 0.5, suggest the existence of a linearly unstable oblique mode, which is independent from either the drift-kink or the tearing ...
G. Lapenta, G. Lapenta, J. U. Brackbill
doaj