Results 111 to 120 of about 67,282 (300)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
, 1956 full view, Saburo's Murakami's repeat performance of Tearing Paper at the Second Gutai Exhibition in ...
Murakami, Saburo
core
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Criteria for Unstable Tearing of Elastomers
, 1985 1. Unstable, or stick-slip, tearing has been evaluated in a series of unfilled elastomers. It was found that unstable tearing in these materials occurs only in well defined regions of temperature and rate.
R. G. Stacer, F. N. Kelley
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Nonlinear evolution of weakly coupled double tearing modes with equilibrium sheared toroidal flow
Nuclear FusionThe nonlinear evolution of weakly coupled double tearing modes (DTMs) with and without sheared toroidal flow is systematically investigated with the three-dimensional, toroidal-geometry, and nonlinear magneto-hydro-dynamics code CLT. Due to the explosive
Y. Y. Ying +5 more
doaj +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Tearing: Breakthrough in Human Emotional Signaling
, 2009 Tearing is not a benign secretory correlate of sadness or other emotional state, but a potent visual cue that adds meaning to human facial expression, the tear effect .
Kurt A. Krosnowski +2 more
core +1 more source
Global linear and nonlinear gyrokinetic simulations of tearing modes
Nuclear FusionTo better understand multi-scale interactions between global tearing modes and microturbulence in the Madison Symmetric Torus (MST) reversed-field pinch (RFP), the global gyrokinetic code Gene is modified to describe global tearing mode instability via a
T. Jitsuk +6 more
doaj +1 more source