Results 91 to 100 of about 67,282 (300)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Calculations in the theory of tearing instability
, 2020 Recent studies have suggested that the tearing instability may play a significant role in magnetic turbulence. In this work we review the theory of the magnetohydrodynamic tearing instability in the general case of an arbitrary tearing parameter, which ...
Gomes Loureiro, Nuno F +1 more
core +1 more source
3D reconnection due to oblique modes: a simulation of Harris current sheets [PDF]
Nonlinear Processes in Geophysics, 2000 Simulations in three dimensions of a Harris current sheet with mass ratio, mi/me = 180, and current sheet thickness, pi/L = 0.5, suggest the existence of a linearly unstable oblique mode, which is independent from either the drift-kink or the tearing ...
G. Lapenta, G. Lapenta, J. U. Brackbill
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Finite element modeling of woven fabric tearing damage
, 2011 In this paper we report the tear damage of woven fabric from experimental investigation and finite element analysis (FEA). Tongue-tearing behaviors of two plain and two twill-woven fabrics were tested to obtain the tearing load— displacement curves and ...
null Hong Hu +4 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Macroscopic trends of neoclassical tearing stability in high-field H-mode tokamak pilot plants
Nuclear FusionThe neoclassical tearing mode (NTM) stability metric—minimum marginally stable island width $w_m^*$ —was compared across 14651 inductive high-field tokamak pilot plant equilibria.
S. Benjamin +8 more
doaj +1 more source
Effects of Tearing on the Perception of Facial Expressions of Emotion
Evolutionary Psychology, 2015 What is the function of emotional tearing? Previous work has found a tear effect, which resolves ambiguity in neutral expressions and increases perceptions of sadness in sad expressions. Tearing, however, is associated with a variety of emotional states,
Lawrence Ian Reed +2 more
doaj +1 more source
Hot Tearing in Cast Aluminum Alloys
, 2011 MPI and CANMET, both members of the Light Metal Alliance, launched a research project to study hot tearing in aluminum alloys. In this project, a reliable test method to quantitatively evaluate hot tearing was developed, and the processing variables ...
Diran Apelian +2 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source