Results 151 to 160 of about 262,135 (326)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf   +10 more
wiley   +1 more source

Microscopic Current Sheets and Fast Tearing Modes in Plasma Turbulence

open access: yesThe Astrophysical Journal
Since the seminal work by W. H. Matthaeus & S. L. Lamkin, a large amount of evidence has been collected over the years that magnetic reconnection can disrupt current sheets formed in turbulence. The details about how this happens, however, are not clear,
Homam Betar, Daniele Del Sarto
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

Stabilization of tearing modes to suppress major disruptions in tokamaks [PDF]

open access: green, 1979
J. A. Holmes   +4 more
openalex   +3 more sources

Magnetic Island Structures Associated with Kinetic Alfvén Solitary Wave in Two-fluid Plasma

open access: yesThe Astrophysical Journal
We investigate the formation of magnetic islands and the onset of tearing instability within kinetic Alfvén solitary waves in a two-fluid space plasma. These localized structures, featuring internal magnetic shear, naturally support magnetic reconnection
Cheong R. Choi   +6 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

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