Results 91 to 100 of about 1,047,530 (303)
Coupled Tearing-Kink Modes and their Interactions with the Sawtooth Crash in HBT-EP [PDF]
This thesis reports observations of kink and tearing modes in the High Beta Tokamak - ExtendedPulse (HBT-EP) experiment. When unstable, these modes could limit the operation of tokamaks used for fusion power by terminating the plasma discharge and ...
Chandra, Rian Naveen
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Threshold condition for nonlinear tearing modes in tokamaks
, 1996 Low-mode-number tearing, mode nonlinear evolution is analyzed emphasizing the need for a threshold condition, to account for observations in tokamaks. The discussion is illustrated by two models recently introduced in the literature.
Callen, J. D., Zabiego, M. F.
core +1 more source
Nonlinear drift tearing modes [PDF]
, 1979 It is shown analytically and with a numerical code that the nonlinear growth and saturation of magnetic islands in tokamaks is not affected by diamagnetic corrections. Diamagnetic effects change the linear growth and introduce mode rotation, which persists in the nonlinear regime.
Monticello, D. A., White, R. B.
openaire +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Interaction of Tearing Modes of Different Pitch in Cylindrical Geometry
, 1977 In cylindrical geometry, we analyze the hypothesis that the major disruption in tokamaks is due to the interaction of tearing modes of different pitch.
Hicks, H. Richard +3 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
From current-driven to neoclassically driven tearing modes [PDF]
In the TCV tokamak, the m/n = 2/1 island is observed in low-density discharges with central electron-cyclotron current drive. The evolution of its width has two distinct growth phases, one of which can be linked to a "conventional" tearing mode driven ...
Reimerdes, H. +3 more
core +2 more sources
Nuclear FusionIn this work, we extend the three-dimensional, nonlinear resistive/two-fluid MHD code CLT to simulate runaway electron physics by implementing a widely adopted fluid runaway electron MHD (RE-MHD) model.
Y. Zhang, W. Zhang, Y.Y. Ying, Z.W. Ma
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source