Results 141 to 150 of about 1,047,530 (303)

Threshold for metastable tearing modes in DIII-D

At sufficiently high poloidal beta beta(theta) and low collisionality, m/n = 3/2 tearing modes are excited in the DIII-D tokamak by a q = 1 sawtooth crash perturbation.
Sauter, O., La Haye, R. J.
core   +1 more source

The seeding of neoclassical tearing modes by resonant magnetic perturbations in the EAST tokamak

Nuclear Fusion
This work presents a robust methodology for effectively distinguishing between the seed island and the onset of the neoclassical tearing mode (NTM) in the EAST tokamak.
Tonghui Shi, L. Wei, Y.W. Sun, H.H. Wang, Q. Ma, E. Li, Y. Zhang, J.P. Qian, L. Zeng, B. Shen, Y.M. Wang, T. Zhang, H.L. Zhao, H.Q. Liu, Z.P. Luo, Y.Y. Li, L.Q. Xu, B. Zhang, M.H. Li, Z.X. Wang, B.L. Ling, X.Z. Gong, B.N. Wan   +22 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Advances on Failure of Carcass Layer in Un-bonded Flexible Riser

Shiyou jixie, 2018
The non-bonded flexible riser is an important part of the subsea production system. The carcass layer is used as the innermost transportation channel of the non-bonded flexible riser, which would damage the entire riser structure when fails, and result ...
Xu Xiaoxuan, Li Wenbo, Cheng Ziyun, Luo Xiaolan, Duan Menglan   +4 more
doaj  

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Modelling and experiment to stabilize disruptive tearing modes in the ITER baseline scenario in DIII-D

Nuclear Fusion
The achievement of high gain, stationary conditions in a tokamak scenario aimed at producing fusion energy in the ITER Project is crucial to the demonstration that this form of energy can be used in future reactors to provide cheap and clean energy ...
F. Turco, T.C. Luce, W. Boyes, J.M. Hanson, A.W. Hyatt   +4 more
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source