Results 71 to 80 of about 146,962 (315)

The effect of acute exercise on environmentally induced symptoms of dry eye

Physiological Reports, 2020
The purpose of this study was to investigate the effects of acute exercise on environmentally induced symptoms of dry eye. Twelve participants without dry eye disease volunteered to complete three experimental visits in a randomized order; (1) control ...
Daniel J. Peart, Ian H. Walshe, Emma L. Sweeney, Emily James, Thomas Henderson, Alasdair F. O'Doherty, Alison M. McDermott   +6 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

On the Possibility of Fluorescent Capture Immunoassays on a Contact Lens

Biosensors
Blood samples and testing are routine in healthcare. Presently, there is a growing interest in using tear samples in place of blood. Tear samples can be obtained non-invasively and collection does not require the skills of a trained phlebotomist.
Kundan Sivashanmugan, E. Albert Reece, Joseph R. Lakowicz   +2 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Tear protein analysis in presumed congenital alacrima

Clinical Ophthalmology, 2018
Shigeharu Yaginuma,1 Yoko Akune,2 Chika Shigeyasu,1,2 Yoji Takano,3 Masakazu Yamada1 1Department of Ophthalmology, Kyorin University School of Medicine, Tokyo 181-8611, Japan; 2Division for Vision Research, National Institute of Sensory Organs, National
Yaginuma S, Akune Y, Shigeyasu C, Takano Y, Yamada M   +4 more
doaj  

“The Philosophy of Tears”: Sense(s) and sensibility in some graveyard poems

Etudes Epistémè, 2016
This essay revisits the involved relationship between the senses, sense and sensibility in four eighteenth-century poems customarily assembled under the term “graveyard poetry” while foregrounding the emotional and material marker, the tear, and its ...
John Baker
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

“[C]losure is something I may never obtain”: (In)consolation in Yewande Omotoso’s An Unusual Grief (2022) and Onyi Nwabineli’s Someday, Maybe (2022)

E-REA
Both Yewande Omotoso’s An Unusual Grief (2022) and Onyi Nwabineli’s Someday, Maybe (2022) address the shattering effects of grief after the sudden and tragic loss of a loved one to suicide.
Cédric COURTOIS
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Diagnostic accuracy in detecting tears in the proximal biceps tendon using standard nonenhancing shoulder MRI [PDF]

, 2014
Samuel A Dubrow,1 Jonathan J Streit,2 Yousef Shishani,2 Mark R Robbin,3 Reuben Gobezie21Department of Orthopedics, Alegent Creighton Clinic, Creighton University School of Medicine, Omaha, NE, USA; 2Department of Orthopedics, Cleveland Shoulder Institute,
Dubrow SA, Streit JJ, Robbin MR, Shishani Y, Gobezie R   +4 more
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