Results 191 to 200 of about 24,612 (260)

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Coronary microvascular dysfunction as an initial clue to the diagnosis of light-chain amyloidosis: a case report. [PDF]

Eur Heart J Case Rep
Bando R, Yagi S, Kadota M, Ise T, Sata M.   +4 more
europepmc   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Delayed Aggressive Local Recurrence of Chondroblastic Osteosarcoma 3 Years After an Excellent Pathological Response: A Case Report. [PDF]

Clin Case Rep
Hannan A, Aslam B, Hastings N, Das DL, Sania Z, Mansoor M, Bibi F, El Abdi K, Najeeb S, Batten K, Kumari M, Sadat SH.   +11 more
europepmc   +1 more source

From Gamma Rays to Green Light: Comparative Efficacy of Indocyanine Green and Technetium-99m in Sentinel Lymph Node Biopsy for Breast Cancer. [PDF]

Med Sci (Basel)
Gâta VA, Ilieș RA, Antone NZ, Pintican R, Nistor-Ciurba CC, Țîțu Ș, Orădan AV, Muntean MV, Filip GG, Irimie A, Achimaș-Cadariu PA.   +10 more
europepmc   +1 more source

How consistent is the interpretation of renal scarring in pediatric patients using technetium-99m dimercaptosuccinic acid scintigraphy. [PDF]

Pediatr Radiol
Naznine M, Chowdhury MEH, Salam A, Shabani A, Kumaresan K, Komarova N, Arya A, Hosokawa T, Al-Nabhani KZ, Abbas TO.   +9 more
europepmc   +1 more source

Concurrent light chain and transthyretin cardiac amyloidosis: A case report and review of the literature. [PDF]

Medicine (Baltimore)
Sun H, Zhang N, Liu X, Wang M, Wang L, Li Y.   +5 more
europepmc   +1 more source

From radiolabeling to receptor quantification: preclinical assessment of [^99mTc]Tc-carvedilol as a cardiac β-adrenoceptor probe. [PDF]

Front Pharmacol
Azhari HF.
europepmc   +1 more source

Index Hepatic Decompensation: Hepatic Hydrothorax Without Signs of Clinically Significant Portal Hypertension Diagnosed With Radioisotope Scintigraphy. [PDF]

ACG Case Rep J
Gunderson AC, Andres B, Gunderson JR, Sabottke C, Savir-Baruch B, Ainapurapu B.   +5 more
europepmc   +1 more source