Results 161 to 170 of about 2,627,818 (309)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Firm-Heterogeneity, Persistent and Transient Technical Inefficiency
This paper provides a new model that disentangles firm effects from persistent (time-invariant/long-term) and transient (time-varying/short-term) technical inefficiency.Bayesian analysis; Markov Chain Monte Carlo; Technical efficiency.
Mike, Tsionas, Subal, Kumbhakar
core
Technical analysis and central bank intervention [PDF]
This paper extends the genetic programming techniques developed in Neely, Weller and Dittmar (1997) to show that technical trading rules can make use of information about U.S. foreign exchange intervention to improve their out-of-sample profitability for
Paul Weller, Christopher Neely
core
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
In order to cope with the water scarcity, Tunisia has to manage efficiently the water demand of the economic and social sectors mainly that of the agricultural irrigated activities.
Chemak, Fraj
core
Technical Efficiency of Pakistan s Manufacturing Sector: A Stochastic Frontier and Data Envelopment Analysis [PDF]
This paper examines the efficiency of the large-scale manufacturing sector of Pakistan using parametric as well as non-parametric frontier techniques.
Ejaz Ghani, Musleh-ud Din, Tariq Mahmood
core
Smoothing techniques for market fluctuation signals
Business: Theory and Practice, 2011 The financial crisis of 2008–2009 caused lots of discussions between Academia and as a result researches on financial crisis and bubble prediction possibilities appeared. Academia shows its growing interest in the issue during the last decade.
Audrius Dzikevičius, Svetlana Šaranda
doaj
The Application of Biomechanics Combined with Human Body Structure in Volleyball Technical Analysis.
Comput Intell Neurosci, 2022 Jiang W, Zhao K.
europepmc +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source