Results 101 to 110 of about 1,368,251 (290)

Analysis and Control of Technical Errors in Machining Technology

open access: yesFrontiers in Science and Engineering
Excessive errors in the machining process affect the performance of mechanical products. In the study of analytical machinery.On the basis of the source of technical error in the processing technology, the source of error is determined, mainly including positioning error,machine tool manufacturing errors and tool geometric errors; The corresponding ...
openaire   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Ceramics from the scythian burial ground of Chineta-2 (Altai)

open access: yesПоволжская археология
The article presents the results of the study of ceramics discovered during the study of barrows of the Scythian-Saka period at the Chineta 2 burial ground, located in the Krasnoshchyokovo district of the Altai Krai. The site contains signs of the burial
Dashkovskiy Petr K.   +1 more
doaj   +1 more source

Closing the Technology Gap: Does Trade Liberalization Really Help? [PDF]

open access: yes
A common theme in discussions of trade reform is the possibility of improved technical efficiency following trade liberalization, This paper presents a conceptual analysis of the likely linkages between trade regimes and technical efficiency.
Dani Rodrik
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Estimating Total Factor Productivity and Its Components: Evidence from Major Manufacturing Industries of Pakistan [PDF]

open access: yes
This paper estimates the trend in total factor productivity growth for eleven major manufacturing sub-sectors/industries listed on Karachi Stock Exchange.
Abdul Qayyum   +3 more
core  

Technology alternatives for the SPS [PDF]

open access: yes, 1980
Emerging technologies may offer advantages over those selected for the reference design adopted for the SPS. While it is not possible to list all the technological innovations that may affect the SPS, it is feasible to develop a systematic methodology ...
Chapman, P. K., Glaser, P.
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Pottery with Graphic Images and Handles from the Settlement of Kizhirovo: Technological Features

open access: yesНижневолжский археологический вестник
Technical and technological analysis was conducted on four vessels with graphical images and one piece of utensil with handles from the settlement of Kizhirovo. It was revealed that the pottery was made of different types of tin clay.
Dmitry V. Selin
doaj   +1 more source

Economic and Environmental Effectiveness of a Technology-based Climate Protocol [PDF]

open access: yes
The present stalemate in climate negotiations has led policy analysts and economists to explore the possible emergence of alternative climate regimes. This paper explores the idea of replacing international cooperation on greenhouse gas emission control ...
Barbara Buchner, Carlo Carraro
core  

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