Results 131 to 140 of about 301,963 (357)

Systematized and Path-independent Measurement of Biased Technical Change [PDF]

The sample-specificity and path-dependence of the data envelopment analysis (DEA) based technical change index as a component of Malmquist indexes prevent us from obtaining overall and systematic information on technical change.
Tsunehiro Otsuki
core  

Kulaika Ceramics of Kireevskoe III Fortified Settlement: Results of Interdisciplinary Research

Вестник Новосибирского государственного университета. Серия: история, филология
Purpose. Kireevskoe III fortified settlement is located in Kozhevnikovsky district of Tomsk region (Russia, Western Siberia) Ceramics of the vasyugan stage of the kulaika culture were studied using technical-technological, petrographic and thermal ...
D. V. Selin, A. A. Maksimova, L. A. Chindina   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Consolidation, Scale Economics and Technological Change in Japanese Banking [PDF]

The paper examines the technological structure of the Japanese banking sector before the onset of the banking crisis and structural reforms of the 90s in order to shade light on the logic of the recent trend to consolidation in the industry.
Solomon Tadesse
core  

Pottery with Graphic Images and Handles from the Settlement of Kizhirovo: Technological Features

Нижневолжский археологический вестник
Technical and technological analysis was conducted on four vessels with graphical images and one piece of utensil with handles from the settlement of Kizhirovo. It was revealed that the pottery was made of different types of tin clay.
Dmitry V. Selin
doaj   +1 more source

GDP per capita vs foreign direct investment: key drivers of a country's technological leadership

Technological and Economic Development of Economy
This study aims to test the hypothesis that countries with high GDP per capita achieve technological leadership not primarily due to their domestic production capacity but through the inflow of foreign direct investment (FDI).
A. Kwiliński
semanticscholar   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Socio-technical transition pathways and social networks: a toolkit for empirical innovation studies [PDF]

In this note we investigate socio-technical transition pathways concentrating our attention on innovation niches formations. Specifically, we present a methodological conceptualization of innovation-niches and propose a preliminary protocol, based on a ...
Piergiuseppe Morone, Antonio Lopolito
core  

Analysis of the principles of working load formation in power drives of construction machines and equipment

Гірничі, будівельні, дорожні та меліоративні машини
The purpose of the proposed article is the analysis of the principles of the formation of the workload on the executive bodies of construction machines and technological equipment, which is due to the need for their improvement in order to improve the ...
Alla Yesipenko, Volodymyr Rashkivskyi, Yuri Zaiets   +2 more
doaj   +1 more source