Results 141 to 150 of about 301,963 (357)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Energy, the Environment, and Technological Change [PDF]

Within the field of environmental economics, the role of technological change has received much attention. The long-term nature of many environmental problems, such as climate change, makes understanding the evolution of technology an important part of ...
Adam B. Jaffe, Richard G. Newell, David Popp   +2 more
core  

Results of the Technical and Technological Analysis of the Wares from the Novoilyinskiy Culture Sites of the Lower Kama Region

Археология евразийских степей
For the first time, a technical and technological analysis of the ceramics of the Novoilyinskiy culture was carried out within the historical and cultural approach proposed by A.A. Bobrinsky.
Olga V. Andreeva
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Technological Diversification and Strategic Alliances [PDF]

This paper examines empirically the relationship between the internal technological profile and the diversification through strategic alliances of the largest 219 industrial firms world-wide. It explores three related issues.
Paola Giuri, Myriam Mariani, John Hagedoorn   +2 more
core  

About the Cultural Affiliation of the Neolithic Monuments at the Kama River Mouth

Археология евразийских степей
The paper deals with the issues of the cultural affiliation of the Neolithic assemblages at the Kama River mouth. The stroked and combed pottery assemblages identified here were initially attributed by A.Kh. Khalikov to the Volga-Kama culture. But, later,
Anatoly V. Somov
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

On Semi-Industrialized Countries and the Acquisition of Technological Capabilities. [PDF]

The last decades have witnessed a breaking down of the hitherto quasi-monopoly in industrial and technological development by highly industrialized countries.
Simon Teitel
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Technological innovation from a system dynamics approach

Región Científica
Technological development and innovation models have evolved over time and in an increasingly globalized context. Their implementation results in the strengthening of competitiveness through the strategic development of human and technical capabilities ...
Martha Iné Kammerer David, Benjamín Murgas Téllez   +1 more
semanticscholar   +1 more source