Results 111 to 120 of about 4,829,333 (325)

Towards a spatially resolved, single-ended TDLAS system for characterizing the distribution of gaseous species

Scientific Reports
Many applications require diagnostics that can quantify the distribution of chemical gas species and gas temperature along a single line-of-sight, which is challenging in process environments with limited optical access.
C. Hansemann, M. Bonarens, J. Emmert, K. J. Daun, S. Wagner   +4 more
doaj   +1 more source

Methods of Technical Prognostics Applicable to Embedded Systems [PDF]

, 2012
Hlavní cílem dizertace je poskytnutí uceleného pohledu na problematiku technické prognostiky, která nachází uplatnění v tzv. prediktivní údržbě založené na trvalém monitorování zařízení a odhadu úrovně degradace systému či jeho zbývající životnosti a to ...
Krupa, Miroslav
core  

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Detailed Analytical Characterization of a Bispecific IgG1 CrossMab Antibody of the Knob-into-Hole Format Applying Various Stress Conditions Revealed Pronounced Stability

ACS Omega, 2022
Ingrid Grunert, Katrin Heinrich, Juliane Ernst, Michael Hingar, Alexandre Briguet, Michael Leiss, Manfred Wuhrer, Dietmar Reusch, Patrick Bulau   +8 more
doaj   +1 more source

NASA CSTI Earth-to-orbit propulsion R/T program overview [PDF]

The topics presented are covered in viewgraph form. The programmatic objectives are to develop and validate technology, design tools, and methodologies needed for the development of a new generation of lower cost, operationally-efficient, long-life ...
Moses, James L.
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A probabilistic method for estimating the technical state of reinforced concrete monolithic slabs of old urban area buildings [PDF]

Инженерно-строительный журнал, 2010
The paper considers the reinforced concrete monolithic floors, realized like beam-type construction. The slab is represented as a complex construction system of some intermediate level, which is a constructive element of the next higher level - the old ...
V.A. Sokolov
doaj  

The efficiency of detecting the failures and troubleshooting while applying technical diagnostics for multi-computer systems

, 2015
This paper presents techniques which base on the concept of flows thinning together with the identification techniques. These methods are proposed to determine the expected number of failures to assess the efficiency of technical diagnostics of ...
Kyaw Zaw Ye, Htike Aung Kyaw, E. M. Portnov, Aleksandar Mikalovish Bain, P. Vasant   +4 more
semanticscholar   +1 more source