Results 91 to 100 of about 3,142,223 (300)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Applying Disability Theory in Technical Education: Toward Inclusive Curriculum and Infrastructure

open access: yesIndonesian Journal of Disability Studies
The present study explores the application of disability theory in technical education, with a view to identifying the key barriers faced by students with disabilities and formulating inclusive strategies. The primary objective is to cultivate equitable
Andrian Riyadi   +3 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Inserción laboral y educación profesional de mujeres en Concepción: Chile (1895-1940)

open access: yesUniversum, 2011
Este trabajo forma parte de una investigación mayor que analiza los distintos actores sociales en el proceso de modernización en Concepción-Chile entre 1880 y 1940.
Alejandra Brito Peña   +1 more
doaj  

PHILOSOPHY’S ROLE AS A FORM OF WORLDVIEW IN MASTERING COMPETENCES BY STUDENTS OF THE TECHNICAL SPECIALISATIONS IN THE MODERN RUSSIA’S HIGHER EDUCATION SYSTEM

open access: yesИнтеграция образования, 2017
Introduction: the central point of the article is the understanding of worldview function of philosophy in modern Russian technical higher education system.
Tatyana V. Lazutina   +2 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Linking Socio-Economic and Policy Variables to Technical Efficiency of Traditional Agricultural Production: Empirical Evidence from Nigeria [PDF]

open access: yes
The major objective of this study was to analyze and link the level of technical efficiency of Nigerian small-scale farmers to specific farmers' socio-economic and policy variables.
Ajibefun, Igbekele A.
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

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