Results 111 to 120 of about 4,214,349 (306)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

A computational solution for bolstering reliability of epigenetic clocks: implications for clinical trials and longitudinal tracking

Nature Aging, 2021
A. Higgins-Chen, Kyra L. Thrush, Yunzhang Wang, Christopher J Minteer, Pei-lun Kuo, Meng Wang, Peter Niimi, Gabriel Sturm, Jue Lin, A. Moore, S. Bandinelli, C. Vinkers, E. Vermetten, B. Rutten, E. Geuze, C. Okhuijsen-Pfeifer, M. van der Horst, S. Schreiter, S. Gutwinski, Jurjen J. Luykx, M. Picard, L. Ferrucci, E. Crimmins, M. Boks, S. Hägg, T. Hu-Seliger, M. Levine   +26 more
semanticscholar   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

On the stress- and strain-based fatigue behavior of welded thick-walled nodular cast iron

Fracture and Structural Integrity
Nodular cast iron (GJS) represents one of the most widely used materials for vehicle, energy and heavy machinery industry. Nevertheless, foundries struggling with the influence of local material defects in GJS like pores, shrinkages and dross often ...
Christoph Bleicher, Steffen Schoenborn, Heinz Kaufmann, Masoud Alizadeh-Sh   +3 more
doaj  

Deep Learning–Assisted Differentiation of Four Peripheral Neuropathies Using Corneal Confocal Microscopy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah, Ioannis N. Petropoulos, Mark Stettner, Maryam Ferdousi, Uazman Alam, Nathan Efron, Ahmed Serag, Rayaz A. Malik   +7 more
wiley   +1 more source

Prediction of Myasthenia Gravis Worsening: A Machine Learning Algorithm Using Wearables and Patient‐Reported Measures

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare disorder characterized by fluctuating muscle weakness with potential life‐threatening crises. Timely interventions may be delayed by limited access to care and fragmented documentation. Our objective was to develop predictive algorithms for MG deterioration using multimodal telemedicine data ...
Maike Stein, Haoqi Sun, Sophie Lehnerer, Lea Gerischer, Maximilian Mönch, Christian Meisel, Andreas Meisel, Pushpa Narayanaswami   +7 more
wiley   +1 more source

Multiple Description Coding For Motion JPEG Video Transmission in UMTS

Majlesi Journal of Electrical Engineering
In this paper, we propose a multiple description video coding system for robust transmission of video signal. We split the video frames into odd and even frames, and encode each frame separately based on JPEG standard.
Alireza Ghasemi, Hossein Khalili, Payman Moallem   +2 more
doaj  

Reduced Muscular Carnosine in Proximal Myotonic Myopathy—A Pilot 1H‐MRS Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Myotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations such as diabetes mellitus, cataracts, and cardiac arrhythmias.
Alexander Gussew, Maryam Kargaran, Maik Rothe, Andreas Deistung, Dietrich Stoevesandt, Walter A. Wohlgemuth, David Strube, Thomas Kendzierski, Anna Katharina Kölsch, Maurits Gerhard Abraham Heuschen, Markus Otto, Alexander Mensch   +11 more
wiley   +1 more source

Fuzzy optimum PSO: PSO with optimized fuzzy controllers

Majlesi Journal of Electrical Engineering
Since the search process of the particle swarm optimization (PSO) technique is non-linear and very complicated, it is hard if not impossible, to mathematically model the search process and dynamically adjust the PSO parameters.
Omid Mokhlessi, Seyed Hamid Zahiri, Nasser Mehrshad   +2 more
doaj