Results 91 to 100 of about 14,757,385 (333)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

Criteria for obtaining the grant of a patent of invention in Peru

open access: yesDerecho PUCP, 2015
This article is a casuistry review of technical reports of several filesregarding applications of patent of invention, in the technological fields of biotechnology, pharmaceutics, chemistry and engineering, where in general and specific criteria are ...
María del Carmen Arana Courrejolles
doaj  

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

Technical Evaluation Report 56: Video-Conferencing with Audio Software

open access: yesInternational Review of Research in Open and Distributed Learning, 2006
An online conference is illustrated using the format of a TV talk show. The conference combined live audio discussion with visual images spontaneously selected by the moderator in the manner of a TV control-room director.
Jon Baggaley, Jim Klaas
doaj  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Technical Evaluation Report 8: Fully Featured vs. Lean-and-Mean?

open access: yesInternational Review of Research in Open and Distributed Learning, 2002
With students in an “Educational Conferencing” graduate course, a comparison was conducted between the merits of an online collaborative package containing a wide range of features and alternative conferencing software containing only a threaded ...
Jon Baggaley
doaj  

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