Results 111 to 120 of about 14,757,385 (333)

Selling “Performance” Assessments with Inaccurate Pictures from Kentucky

open access: yesNonpartisan Education Review, 2015
A new white paper from Ace Parsi and Linda Darling-Hammond, “Performance Assessments: How State Policy Can Advance Assessments for 21st Century Learning,” has a discussion on Page 7 about supposed success of the Kentucky Instructional Results ...
Richard G. Innes
doaj  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

The Possibilities of the Enterprise. Issue of Motor Vechicles for MilitaryTechnical Purposes

open access: yesМеханика машин, механизмов и материалов, 2015
The report presents the technical capabilities of JSC "Minsk Wheel Tractor Plant" and the overview of produced motor vehicles for military-technical purposes.
Yu.I. Nikolaev
doaj  

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Technical Evaluation Report 14: Chat and Instant Messaging Systems (synchronous): Report 2/ 3

open access: yesInternational Review of Research in Open and Distributed Learning, 2002
This study extends the earlier review of online chat systems (Report 6), by reviewing a further seven products that provide text-based instant messaging (IM).
Ellen Kinsel   +4 more
doaj  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Technical Report for HW2VEC -- A Graph Learning Tool for Automating\n Hardware Security [PDF]

open access: green, 2021
Yasamin Moghaddas   +4 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

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