Results 81 to 90 of about 14,757,385 (333)

Technical Evaluation Report 10: Evaluating Vendor Supplied Information

International Review of Research in Open and Distributed Learning, 2002
Distance educators are not normally equipped by their training or experience for the complex task of evaluating technologies. One of the areas of potential disadvantage is in interpreting information provided by vendors themselves, and in relating ...
Patrick J. Fahy
doaj  

Peer review of GPT-4 technical report and systems card

PLOS Digital Health
The study provides a comprehensive review of OpenAI’s Generative Pre-trained Transformer 4 (GPT-4) technical report, with an emphasis on applications in high-risk settings like healthcare. A diverse team, including experts in artificial intelligence (AI),
Jack Gallifant, Amelia Fiske, Yulia A. Levites Strekalova, Juan S Osorio-Valencia, Rachael L. Parke, Rogers Mwavu, Nicole Martinez, J. Gichoya, Marzyeh Ghassemi, Dina Demner-Fushman, Liam G. McCoy, L. A. Celi, Robin L. Pierce   +12 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Technical Evaluation Report 29: Integrated Learning Management Systems

International Review of Research in Open and Distributed Learning, 2004
Four integrated learning management packages were reviewed: CentraOne, IntraLearn, Lyceum, and Silicon Chalk. These products provide different combinations of synchronous and asynchronous tools.
Linda Schwartz, Harry Doxsee, Mary Cossarin, Sharon Clark   +3 more
doaj  

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Technical Evaluation Report 18. Internet Audio Products (Update)

International Review of Research in Open and Distributed Learning, 2003
The benefits in distance education of collaborative interaction via online, synchronous audio methods have been discussed in previous reports in this series. As the months go by, new software products are continually introduced to the market and existing
Jim Depow, Jim Klaas, Norine Wark
doaj  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Technical Evaluation Report 19: Integrated Course Delivery Packages

International Review of Research in Open and Distributed Learning, 2003
This report contains updates of three products: Elluminate, LearnLinc, and Wimba. Each features audio communication, both asynchronous and synchronous, and has been selected for this report to complement the preceding review of Internet audio products ...
Judy Annis, Tracy Hensel, Patricia Lundstrom, Richard Jones   +3 more
doaj  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source