Results 131 to 140 of about 1,197,354 (304)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

TECHNICAL AND NATURAL SCIENCES TEACHING AT TECHNICAL FACULTY [PDF]

Trends in Education, 2016
openaire   +1 more source

IMAGE PROCESSING IN COLOR: WIENER FILTERS FOR RESTORING AND REGISTERING THE SPECTRAL COMPONENTS OF POLYCHROMATIC PICTURES

, 1969
QC 351 A7 no. 46Simple inverse filtering of each spectral component of a color picture can lead to serious misregistration of the restorations. This is a consequence of the nonlinearity of the photographic process, which distorts edges of objects in an ...
Frieden, B. Roy
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

A NEW RETINAL MODEL AND ITS APPLICATION TO THE COMPUTER ANALYSIS OF AERIAL PHOTOGRAPHS

, 1971
QC 351 A7 no. 70In order to find a new and more economical method for the computer detection of object outlines in aerial photographs, the human visual system is considered. This leads to the concept of the human retina as a matrix of light receptors and
Sadowski, Alexander M.
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Bridging language and data: Transforming agricultural curricula for data analytics through linguistic insights. [PDF]

PLoS One
Xu Z, Ahn J, Ma S, Adyemi AE, Choudhury FH, Zhuang X, Landaverde R, Wingenbach G.   +7 more
europepmc   +1 more source

Lens Design With Large Computers Report on the International Conference Rochester, New York July 5-8, 1966

, 1967
QC 351 A7 no. 14Lens designers who use automatic programs and large computers are no longer considered to be pioneers but are now an integral part of the world's rapidly-expanding optical industry. Various techniques of automatic correction, though still
Wilkerson, Gary W., Lytle, John D.
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Correction: Cleats on, battle real: sustainability and gender equality in women's football. [PDF]

Front Psychol
Ornek S, Besiktas MY, Terekli MS, Erkan M, Aksakal N.   +4 more
europepmc   +1 more source